The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

Miriam A. Lynn; Georgina Eden; Feargal J. Ryan; Julien Bensalem; Xuemin Wang; Stephen J. Blake; Jocelyn M. Choo; Yee Tee Chern; Anastasia Sribnaia; Jane James; Saoirse C. Benson; Lauren Sandeman; Jianling Xie; Sofia Hassiotis; Emily W. Sun; Alyce M. Martin; Marianne D. Keller; Damien J. Keating; Timothy J. Sargeant; Christopher G. Proud; Steve L. Wesselingh; Geraint B. Rogers; David J. Lynn

doi:10.1016/j.celrep.2021.109564

The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

Miriam A. Lynn, Georgina Eden, Feargal J. Ryan, Julien Bensalem, Xuemin Wang, Stephen J. Blake, Jocelyn M. Choo, Yee Tee Chern, Anastasia Sribnaia, Jane James, Saoirse C. Benson, Lauren Sandeman, Jianling Xie, Sofia Hassiotis, Emily W. Sun, Alyce M. Martin, Marianne D. Keller, Damien J. Keating, Timothy J. Sargeant, Christopher G. ProudSteve L. Wesselingh, Geraint B. Rogers, David J. Lynn

College of Medicine and Public Health

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Abstract

Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.

Original language	English
Article number	109564
Number of pages	21
Journal	Cell Reports
Volume	36
Issue number	8
DOIs	https://doi.org/10.1016/j.celrep.2021.109564
Publication status	Published - 24 Aug 2021

Keywords

antibiotics
gut
immunity
inflammaging
lifespan
longevity
metabolism
microbiota
recolonization
vaccine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Lynn, M. A., Eden, G., Ryan, F. J., Bensalem, J., Wang, X., Blake, S. J., Choo, J. M., Chern, Y. T., Sribnaia, A., James, J., Benson, S. C., Sandeman, L., Xie, J., Hassiotis, S., Sun, E. W., Martin, A. M., Keller, M. D., Keating, D. J., Sargeant, T. J., ... Lynn, D. J. (2021). The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life. Cell Reports, 36(8), Article 109564. https://doi.org/10.1016/j.celrep.2021.109564

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title = "The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life",

abstract = "Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.",

keywords = "antibiotics, gut, immunity, inflammaging, lifespan, longevity, metabolism, microbiota, recolonization, vaccine",

author = "Lynn, {Miriam A.} and Georgina Eden and Ryan, {Feargal J.} and Julien Bensalem and Xuemin Wang and Blake, {Stephen J.} and Choo, {Jocelyn M.} and Chern, {Yee Tee} and Anastasia Sribnaia and Jane James and Benson, {Saoirse C.} and Lauren Sandeman and Jianling Xie and Sofia Hassiotis and Sun, {Emily W.} and Martin, {Alyce M.} and Keller, {Marianne D.} and Keating, {Damien J.} and Sargeant, {Timothy J.} and Proud, {Christopher G.} and Wesselingh, {Steve L.} and Rogers, {Geraint B.} and Lynn, {David J.}",

year = "2021",

month = aug,

day = "24",

doi = "10.1016/j.celrep.2021.109564",

language = "English",

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Lynn, MA, Eden, G, Ryan, FJ, Bensalem, J, Wang, X, Blake, SJ, Choo, JM, Chern, YT, Sribnaia, A, James, J, Benson, SC, Sandeman, L, Xie, J, Hassiotis, S, Sun, EW, Martin, AM, Keller, MD, Keating, DJ, Sargeant, TJ, Proud, CG, Wesselingh, SL , Rogers, GB & Lynn, DJ 2021, 'The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life', Cell Reports, vol. 36, no. 8, 109564. https://doi.org/10.1016/j.celrep.2021.109564

TY - JOUR

T1 - The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

AU - Lynn, Miriam A.

AU - Eden, Georgina

AU - Ryan, Feargal J.

AU - Bensalem, Julien

AU - Wang, Xuemin

AU - Blake, Stephen J.

AU - Choo, Jocelyn M.

AU - Chern, Yee Tee

AU - Sribnaia, Anastasia

AU - James, Jane

AU - Benson, Saoirse C.

AU - Sandeman, Lauren

AU - Xie, Jianling

AU - Hassiotis, Sofia

AU - Sun, Emily W.

AU - Martin, Alyce M.

AU - Keller, Marianne D.

AU - Keating, Damien J.

AU - Sargeant, Timothy J.

AU - Proud, Christopher G.

AU - Wesselingh, Steve L.

AU - Rogers, Geraint B.

AU - Lynn, David J.

PY - 2021/8/24

Y1 - 2021/8/24

N2 - Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.

AB - Studies investigating whether there is a causative link between the gut microbiota and lifespan have largely been restricted to invertebrates or to mice with a reduced lifespan because of a genetic deficiency. We investigate the effect of early-life antibiotic exposure on otherwise healthy, normal chow-fed, wild-type mice, monitoring these mice for more than 700 days in comparison with untreated control mice. We demonstrate the emergence of two different low-diversity community types, post-antibiotic microbiota (PAM) I and PAM II, following antibiotic exposure. PAM II but not PAM I mice have impaired immunity, increased insulin resistance, and evidence of increased inflammaging in later life as well as a reduced lifespan. Our data suggest that differences in the composition of the gut microbiota following antibiotic exposure differentially affect host health and longevity in later life.

KW - antibiotics

KW - gut

KW - immunity

KW - inflammaging

KW - lifespan

KW - longevity

KW - metabolism

KW - microbiota

KW - recolonization

KW - vaccine

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DO - 10.1016/j.celrep.2021.109564

M3 - Article

AN - SCOPUS:85113355621

SN - 2211-1247

VL - 36

JO - Cell Reports

JF - Cell Reports

IS - 8

M1 - 109564

ER -

The composition of the gut microbiota following early-life antibiotic exposure affects host health and longevity in later life

Abstract

Keywords

UN SDGs

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