TY - JOUR
T1 - The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. II: adenomyosis and macrophages
AU - Tremellen, Kelton
AU - Russell, Peter
PY - 2012/1
Y1 - 2012/1
N2 - Adenomyosis, a condition usually associated with multiparity, is not generally seen as a cause of infertility. However, recent studies have reported a reduction in IVF implantation rates and a link with miscarriage, suggesting that adenomyosis may interfere with successful implantation. To investigate this hypothesis, the clinical records and laboratory results, which routinely include immunohistochemical examination of a late luteal phase endometrial biopsy for leukocytes, were retrospectively reviewed for 64 women with implantation failure and who previously had been screened for the presence of adenomyosis by pelvic MRI.The presence of either diffuse or " adenomyoma" type of adenomyosis was associated with a marked increase (p= 0.004) in the density of macrophages and natural killer cells in the endometrial stroma, compared to those women with mild focal adenomyosis or no disease. These findings point to an immunological mechanism by which adenomyosis might interfere with successful embryo implantation.
AB - Adenomyosis, a condition usually associated with multiparity, is not generally seen as a cause of infertility. However, recent studies have reported a reduction in IVF implantation rates and a link with miscarriage, suggesting that adenomyosis may interfere with successful implantation. To investigate this hypothesis, the clinical records and laboratory results, which routinely include immunohistochemical examination of a late luteal phase endometrial biopsy for leukocytes, were retrospectively reviewed for 64 women with implantation failure and who previously had been screened for the presence of adenomyosis by pelvic MRI.The presence of either diffuse or " adenomyoma" type of adenomyosis was associated with a marked increase (p= 0.004) in the density of macrophages and natural killer cells in the endometrial stroma, compared to those women with mild focal adenomyosis or no disease. These findings point to an immunological mechanism by which adenomyosis might interfere with successful embryo implantation.
KW - Adenomyosis
KW - CD163
KW - Endometrium
KW - IVF
KW - Macrophages
UR - http://www.scopus.com/inward/record.url?scp=84856386435&partnerID=8YFLogxK
U2 - 10.1016/j.jri.2011.12.001
DO - 10.1016/j.jri.2011.12.001
M3 - Article
SN - 0165-0378
VL - 93
SP - 58
EP - 63
JO - JOURNAL OF REPRODUCTIVE IMMUNOLOGY
JF - JOURNAL OF REPRODUCTIVE IMMUNOLOGY
IS - 1
ER -