The effect of angiotensin converting enzyme inhibitors (ACE-I) and selective β1-antagonists on bronchial reactivity and the cough reflex in man

R. I. Uzubalis, D. B. Frewin, M. K. Bushell, R. D. McEvoy

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12 Citations (Scopus)


The non-specific bronchial reactivity and cough threshold of hypertensive patients on an ACE-I monotherapy regimen (either captopril or enalapril), a β1-antagonist monotherapy regimen (either atenolol or metoprolol) or a combination of an ACE-I with a β1-antagonist were determined in the present study. Forty-six hypertensives who were on these medications performed a histamine inhalation test (to assess bronchial reactivity) and a further 36 of these individuals participated in the citric acid test (to assess cough threshold). A control cohort consisting of 25 age-matched, drug-free subjects also performed the citric acid test. The incidence of bronchial hyperreactivity was not significantly different between the ACE-I monotherapy regimen and the β1-antagonist monotherapy regimen (Chi-squared =0.248). However, when the monotherapy regimens were pooled and compared with the ACE-I and β1-antagonist combination regimen, the combination regimen was found to be associated with a significantly higher incidence of bronchial hyperreactivity (Chi-squared =6.69). No difference was observed between the age-matched controls and the hypertensive patients in terms of their cough threshold.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalEuropean Journal of Clinical Pharmacology
Issue number5
Publication statusPublished - 1 Sep 1989
Externally publishedYes


  • asthma
  • atenolol
  • captopril
  • cough threshold
  • enalapril
  • histamine inhalation test
  • metoprolol

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