The Effect of Antioxidant Supplementation on Fatigue during Exercise: Potential Role for NAD(+)(H)

John Mach, Adrian Midgley, Steven Dank, Ross Grant, David Bentley

    Research output: Contribution to journalArticle

    16 Citations (Scopus)

    Abstract

    This study compared serum pyridine levels (NAD+ /NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway©). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD+ levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD+ and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.

    Original languageEnglish
    Pages (from-to)319-329
    Number of pages11
    JournalNutrients
    Volume2
    Issue number4
    DOIs
    Publication statusPublished - 2010

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