The effect of benz pyrones on the maximal swelling volume and resolution of thermally induced oedema in the rat: a determination of their optimal frequency of administration

A number of members of the benzpyrone group have been shown to be very effective in reducing a high protein oedema. However the time course of oedema formation and resolution is altered by their administration. Generally they increased the rate of swelling of the oedema. This was attributed to an increased injury to the vascular endothelium which allowed extra protein and fluid to enter the tissues. However this slight inflow was more than compensated for by the stimulation of proteolysis. This resulted in a net removal of protein. The effects of proteolysis were shown by a reduction in maximal swelling volumes, the time at which the maximal swelling occurred and a more rapid rate of resolution. Optimal dose levels and frequency of administration of the various benzpyrones were determined.