The effect of coumarin (5,6 benzo-α-pyrone) on elicited members of the mononuclear system in dogs with chronic secondary lymphedema

N. B. Piller, L. Clodius

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The effect of coumarin is investigated on the morphological features of members of the mononuclear phagocytic system (MPS) attaching to subcutaneously (s.c.) implanted coverslips in "normal" and chronically lymphedematous tissues. In untreated "normal" tissues there was no attachment suggesting that the presence of lymphedema elsewhere influences MPS activity. Coumarin restored attachment proportions to those found in normal tissues of dogs with no lymphedema. In lymphedema, coumarin significantly increased the proportion of macrophages which were round with less than ten pseudopods (new recruits) and the proportion with distinct pseudopods combined with more than ten vacuoles (active elicited members of the MPS). Coumarin resulted in a significant decline in the proportion of macrophages which were round and with more than ten apparently lipid-containing vacuoles, suggesting a facilitation of their removal to other sites.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalResearch in Experimental Medicine
Volume186
Issue number2
DOIs
Publication statusPublished - 1 Mar 1986
Externally publishedYes

Keywords

  • Coumarin
  • Dogs
  • Mononuclear phagocytic system
  • Secondary obstructive lymphedema

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