The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis

Hedayat Jafari, Salehi Hikooei Marzieh, Seyed Afshin Shorofi, Javad Setareh, Mahmood Moosazadeh, Fatemeh Espahbodi, Majid Saeedi, Paul Arbon, Pooyan Ghorbani Vajargah, Samad Karkhah

Research output: Contribution to journalArticlepeer-review

Abstract

Background: and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis. 

Materials and methods: In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions. 

Results: This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27. 

Conclusion: According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.

Original languageEnglish
Pages (from-to)105-110
Number of pages6
JournalSleep Medicine
Volume111
Early online date15 Sept 2023
DOIs
Publication statusPublished - Nov 2023

Keywords

  • Cognitive status
  • Hemodialysis
  • Melatonin
  • Pittsburgh
  • Sleep quality

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