The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis

Hedayat Jafari; Salehi Hikooei Marzieh; Seyed Afshin Shorofi; Javad Setareh; Mahmood Moosazadeh; Fatemeh Espahbodi; Majid Saeedi; Paul Arbon; Pooyan Ghorbani Vajargah; Samad Karkhah

doi:10.1016/j.sleep.2023.09.011

The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis

Hedayat Jafari, Salehi Hikooei Marzieh, Seyed Afshin Shorofi, Javad Setareh, Mahmood Moosazadeh, Fatemeh Espahbodi, Majid Saeedi, Paul Arbon, Pooyan Ghorbani Vajargah, Samad Karkhah

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Background: and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis.

Materials and methods: In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions.

Results: This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27.

Conclusion: According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.

Original language	English
Pages (from-to)	105-110
Number of pages	6
Journal	Sleep Medicine
Volume	111
Early online date	15 Sept 2023
DOIs	https://doi.org/10.1016/j.sleep.2023.09.011
Publication status	Published - Nov 2023

Keywords

Cognitive status
Hemodialysis
Melatonin
Pittsburgh
Sleep quality

Access to Document

10.1016/j.sleep.2023.09.011Licence: In Copyright

Cite this

@article{3241c800e4dd462faf5e1059bf6ba9aa,

title = "The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis",

abstract = "Background: and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis. Materials and methods: In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions. Results: This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27. Conclusion: According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.",

keywords = "Cognitive status, Hemodialysis, Melatonin, Pittsburgh, Sleep quality",

author = "Hedayat Jafari and Marzieh, {Salehi Hikooei} and Shorofi, {Seyed Afshin} and Javad Setareh and Mahmood Moosazadeh and Fatemeh Espahbodi and Majid Saeedi and Paul Arbon and {Ghorbani Vajargah}, Pooyan and Samad Karkhah",

year = "2023",

month = nov,

doi = "10.1016/j.sleep.2023.09.011",

language = "English",

volume = "111",

pages = "105--110",

journal = "Sleep Medicine",

issn = "1389-9457",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis

AU - Jafari, Hedayat

AU - Marzieh, Salehi Hikooei

AU - Shorofi, Seyed Afshin

AU - Setareh, Javad

AU - Moosazadeh, Mahmood

AU - Espahbodi, Fatemeh

AU - Saeedi, Majid

AU - Arbon, Paul

AU - Ghorbani Vajargah, Pooyan

AU - Karkhah, Samad

PY - 2023/11

Y1 - 2023/11

N2 - Background: and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis. Materials and methods: In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions. Results: This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27. Conclusion: According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.

AB - Background: and purpose: This study aimed to investigate the effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis. Materials and methods: In this randomized controlled clinical trial, 102 eligible individuals were assigned to two equal intervention and control groups. The intervention group received melatonin 3 mg tablets half an hour before going to bed for six weeks, while the control group was given a placebo with similar conditions. Results: This study had 102 participants who were divided into intervention and control groups. The mean age of the participants was 58.30 (SD = 12.10). Among the participants, 54.90% were female. Moreover, 33.33% of the individuals received dialysis for four years or longer. After the intervention, the mean and standard deviation of the Pittsburgh Sleep Quality Index (PSQI) was 12.66 (SD = 3.09) in the intervention group and 18.86 (SD = 3.8) in the control group (P < 0.001). Moreover, the mean sleep quality index in the intervention group showed a statistically significant difference before and after the intervention (P < 0.001); the PSQI score declined from 20.21 to 12.66. Likewise, there was a statistically significant difference between the two groups after intervention in the mean Montreal Cognitive Assessment (MoCA) index (P = 0.002); it was 24.27 (SD = 3.42) in the intervention group and 22.15 (SD = 2.3) in the control group. The mean MoCA score in the intervention group showed a significant difference before and after the intervention (P < 0.001), increasing from 21.19 to 24.27. Conclusion: According to the study's findings, melatonin can improve individuals undergoing hemodialysis' cognitive function and sleep quality.

KW - Cognitive status

KW - Hemodialysis

KW - Melatonin

KW - Pittsburgh

KW - Sleep quality

UR - http://www.scopus.com/inward/record.url?scp=85172341693&partnerID=8YFLogxK

U2 - 10.1016/j.sleep.2023.09.011

DO - 10.1016/j.sleep.2023.09.011

M3 - Article

AN - SCOPUS:85172341693

SN - 1389-9457

VL - 111

SP - 105

EP - 110

JO - Sleep Medicine

JF - Sleep Medicine

ER -

The effect of melatonin on sleep quality and cognitive function of individuals undergoing hemodialysis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this