The effect of oral cisapride premedication on fasting gastric volumes

M. T. Kluger; H. Owen; J. L. Plummer; C. McLean

doi:10.1177/0310057x9502300605

The effect of oral cisapride premedication on fasting gastric volumes

M. T. Kluger, H. Owen, J. L. Plummer, C. McLean

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The aim of this study was to determine whether fasting gastric volumes could be reduced by preoperative administration of cisapride. One hundred and twenty-one patients undergoing elective general anaesthesia were randomly allocated to receive either cisapride 20 mg plus diazepam 10 mg or placebo tablets plus diazepam 10 mg, two hours prior to induction. Immediately following induction blind gastric aspiration was performed using a 16 Fr multiorificed orogastric tube. Gastric volume, pH, and cisapride blood concentration were measured at this time. Gastric volumes were significantly smaller in the cisapride group, 20.5 (SD 22.2) ml compared to placebo 28.2 (SD 26.0) ml but there was no significant difference with respect to pH. Some patients in both groups had large gastric volumes despite fasting. No significant adverse effects were noted with cisapride.

Original language	English
Pages (from-to)	687-690
Number of pages	4
Journal	Anaesthesia and Intensive Care
Volume	23
Issue number	6
DOIs	https://doi.org/10.1177/0310057x9502300605
Publication status	Published - Dec 1995

Keywords

Anaesthesia, general, complications: Gastric stasis, aspiration, prevention, cisapride

Access to Document

10.1177/0310057x9502300605Licence: In Copyright

Cite this

@article{06b94ebda3664fc280f4878e9c1c2a85,

title = "The effect of oral cisapride premedication on fasting gastric volumes",

abstract = "The aim of this study was to determine whether fasting gastric volumes could be reduced by preoperative administration of cisapride. One hundred and twenty-one patients undergoing elective general anaesthesia were randomly allocated to receive either cisapride 20 mg plus diazepam 10 mg or placebo tablets plus diazepam 10 mg, two hours prior to induction. Immediately following induction blind gastric aspiration was performed using a 16 Fr multiorificed orogastric tube. Gastric volume, pH, and cisapride blood concentration were measured at this time. Gastric volumes were significantly smaller in the cisapride group, 20.5 (SD 22.2) ml compared to placebo 28.2 (SD 26.0) ml but there was no significant difference with respect to pH. Some patients in both groups had large gastric volumes despite fasting. No significant adverse effects were noted with cisapride.",

keywords = "Anaesthesia, general, complications: Gastric stasis, aspiration, prevention, cisapride",

author = "Kluger, {M. T.} and H. Owen and Plummer, {J. L.} and C. McLean",

year = "1995",

month = dec,

doi = "10.1177/0310057x9502300605",

language = "English",

volume = "23",

pages = "687--690",

journal = "Anaesthesia and Intensive Care",

issn = "0310-057X",

publisher = "Australian Society of Anaesthetists",

number = "6",

}

TY - JOUR

T1 - The effect of oral cisapride premedication on fasting gastric volumes

AU - Kluger, M. T.

AU - Owen, H.

AU - Plummer, J. L.

AU - McLean, C.

PY - 1995/12

Y1 - 1995/12

N2 - The aim of this study was to determine whether fasting gastric volumes could be reduced by preoperative administration of cisapride. One hundred and twenty-one patients undergoing elective general anaesthesia were randomly allocated to receive either cisapride 20 mg plus diazepam 10 mg or placebo tablets plus diazepam 10 mg, two hours prior to induction. Immediately following induction blind gastric aspiration was performed using a 16 Fr multiorificed orogastric tube. Gastric volume, pH, and cisapride blood concentration were measured at this time. Gastric volumes were significantly smaller in the cisapride group, 20.5 (SD 22.2) ml compared to placebo 28.2 (SD 26.0) ml but there was no significant difference with respect to pH. Some patients in both groups had large gastric volumes despite fasting. No significant adverse effects were noted with cisapride.

AB - The aim of this study was to determine whether fasting gastric volumes could be reduced by preoperative administration of cisapride. One hundred and twenty-one patients undergoing elective general anaesthesia were randomly allocated to receive either cisapride 20 mg plus diazepam 10 mg or placebo tablets plus diazepam 10 mg, two hours prior to induction. Immediately following induction blind gastric aspiration was performed using a 16 Fr multiorificed orogastric tube. Gastric volume, pH, and cisapride blood concentration were measured at this time. Gastric volumes were significantly smaller in the cisapride group, 20.5 (SD 22.2) ml compared to placebo 28.2 (SD 26.0) ml but there was no significant difference with respect to pH. Some patients in both groups had large gastric volumes despite fasting. No significant adverse effects were noted with cisapride.

KW - Anaesthesia, general, complications: Gastric stasis, aspiration, prevention, cisapride

UR - http://www.scopus.com/inward/record.url?scp=0029608837&partnerID=8YFLogxK

U2 - 10.1177/0310057x9502300605

DO - 10.1177/0310057x9502300605

M3 - Article

C2 - 8669601

AN - SCOPUS:0029608837

VL - 23

SP - 687

EP - 690

JO - Anaesthesia and Intensive Care

JF - Anaesthesia and Intensive Care

SN - 0310-057X

IS - 6

ER -

The effect of oral cisapride premedication on fasting gastric volumes

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this