The effect of positive surgical margins on cancer endpoints after radical prostatectomy: a state-wide study from the SA-PCCOC database

K. Beckman; M. O'Callaghan; K. Moretti; A. Vincent; N. Brook

doi:10.1111/bju.14723

The effect of positive surgical margins on cancer endpoints after radical prostatectomy: a state-wide study from the SA-PCCOC database

K. Beckman, M. O'Callaghan, K. Moretti, A. Vincent, N. Brook

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Introduction and Objectives: This study describes the associations between PSM and clinical endpoints after radical prostatectomy (RP) in a cohort of South Australian men with prostate cancer (RP). Positive surgical margins (PSM) occur in 13–35% of RP, and are considered an adverse outcome indicting failure of surgery to adequately clear cancer. PSMs confer an increased risk of biochemical recurrence (BCR) compared to a negative surgical margin, but how the more robust clinical endpoints are affected is more controversial. Importantly, a PSM may be an independent trigger for adjuvant radiotherapy, with added morbidity.

Original language	English
Pages (from-to)	18-19
Number of pages	2
Journal	BJU International
Volume	123
Issue number	S2
DOIs	https://doi.org/10.1111/bju.14723
Publication status	Published - 1 Apr 2019
Externally published	Yes
Event	2019 Urological Society of Australia and New Zealand Annual Scientific Meeting - Brisbane, Australia Duration: 13 Apr 2019 → 16 Apr 2019

Keywords

Prostate cancer
Radical prostatectomy
South Australia
Clinical endpoints

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10.1111/bju.14723Licence: In Copyright

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title = "The effect of positive surgical margins on cancer endpoints after radical prostatectomy: a state-wide study from the SA-PCCOC database",

abstract = "Introduction and Objectives: This study describes the associations between PSM and clinical endpoints after radical prostatectomy (RP) in a cohort of South Australian men with prostate cancer (RP). Positive surgical margins (PSM) occur in 13–35% of RP, and are considered an adverse outcome indicting failure of surgery to adequately clear cancer. PSMs confer an increased risk of biochemical recurrence (BCR) compared to a negative surgical margin, but how the more robust clinical endpoints are affected is more controversial. Importantly, a PSM may be an independent trigger for adjuvant radiotherapy, with added morbidity.",

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T2 - 2019 Urological Society of Australia and New Zealand Annual Scientific Meeting

AU - Beckman, K.

AU - O'Callaghan, M.

AU - Moretti, K.

AU - Vincent, A.

AU - Brook, N.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Introduction and Objectives: This study describes the associations between PSM and clinical endpoints after radical prostatectomy (RP) in a cohort of South Australian men with prostate cancer (RP). Positive surgical margins (PSM) occur in 13–35% of RP, and are considered an adverse outcome indicting failure of surgery to adequately clear cancer. PSMs confer an increased risk of biochemical recurrence (BCR) compared to a negative surgical margin, but how the more robust clinical endpoints are affected is more controversial. Importantly, a PSM may be an independent trigger for adjuvant radiotherapy, with added morbidity.

AB - Introduction and Objectives: This study describes the associations between PSM and clinical endpoints after radical prostatectomy (RP) in a cohort of South Australian men with prostate cancer (RP). Positive surgical margins (PSM) occur in 13–35% of RP, and are considered an adverse outcome indicting failure of surgery to adequately clear cancer. PSMs confer an increased risk of biochemical recurrence (BCR) compared to a negative surgical margin, but how the more robust clinical endpoints are affected is more controversial. Importantly, a PSM may be an independent trigger for adjuvant radiotherapy, with added morbidity.

KW - Prostate cancer

KW - Radical prostatectomy

KW - South Australia

KW - Clinical endpoints

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JO - BJU International

JF - BJU International

IS - S2

Y2 - 13 April 2019 through 16 April 2019

ER -

The effect of positive surgical margins on cancer endpoints after radical prostatectomy: a state-wide study from the SA-PCCOC database

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