The effects of an irreversible dopamine receptor antagonist, N- ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), on the regulation of muscle tone in the rat: The role of the substantia nigra

Kim M. Hemsley, Ann D. Crocker

    Research output: Contribution to journalArticlepeer-review

    15 Citations (Scopus)

    Abstract


    Recent evidence has questioned the view that the increased muscle tone of Parkinson's disease results solely from reduced release of dopamine in the striatum, by emphasising the important role of the substantia nigra. The aim of the current study was to compare the effects on muscle tone of inactivating D1 and D2 dopamine receptors throughout the brain with those seen following their inactivation only in the substantia nigra. Inactivation of dopamine receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline injected either intraperitoneally, or bilaterally into the substantia nigra, resulted in similar increases in muscle tone, measured as changes in tonic electromyographic (EMG) activity. The magnitude and onset of EMG increases was related to the level of dopamine receptor inactivation. The results are consistent with the hypothesis that nigral dopamine mechanisms play a key role in the maintenance of muscle tone.

    Original languageEnglish
    Pages (from-to)77-80
    Number of pages4
    JournalNeuroscience letters
    Volume251
    Issue number2
    DOIs
    Publication statusPublished - 24 Jul 1998

    Keywords

    • Basal ganglia
    • Dopamine receptor
    • Muscle tone
    • N- Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline
    • Rat
    • Substantia nigra

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