The effects of comorbidity on colorectal cancer mortality in an Australian cancer population

Maleshwane Lettie Pule, Elizabeth Buckley, Theophile Niyonsenga, David Roder

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

This study estimated the absolute risk of colorectal cancer (CRC) specific and other-cause mortality using data from the population-based South Australian Cancer Registry. The impact of competing risks on the absolute and relative risks of mortality in cases with and without comorbidity was also investigated. The study included 7115 staged, primary CRC cases diagnosed between 2003 and 2012 with at least one year of follow-up. Comorbidities were classified according to Charlson, Elixhauser and C3 comorbidity indices, using hospital inpatient diagnoses occurring five years before CRC diagnosis. To estimate the differences in measures of association, the subdistribution hazard ratios (sHR) for the effect of comorbidity on mortality from the Fine and Gray model were compared to the cause-specific hazards (HR) from Cox regression model. CRC was most commonly diagnosed in people aged ≧ 70 years. In cases without comorbidity, the 10-year cumulative probability of CRC and other cause mortality were 37.1% and 17.2% respectively. In cases with Charlson comorbidity scores ≥2, the 10-year cumulative probability of CRC-specific and other cause mortality was 45.5% and 32.2%, respectively. Comorbidity was associated with increased CRC-specific and other cause mortality and the effect differed only marginally based on comorbidity index used.

Original languageEnglish
Article number8580
Number of pages10
JournalScientific Reports
Volume9
Issue number1
Early online date12 Jun 2019
DOIs
Publication statusPublished - 1 Dec 2019
Externally publishedYes

Keywords

  • Cancer epidemiology
  • Epidemiology

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