The effects of indomethacin in treated hypertensive patients

L. M.H. Wing, A. J.C. Bune, J. P. Chalmers, J. R. Graham, M. J. West

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21 Citations (Scopus)

Abstract

1. Twelve treated hypertensive patients (ages 58–71 years) who had also been treated for joint disease participated in a randomized double‐blind crossover placebo‐controlled study to investigate the effects of indomethacin (25 mg three times daily) on blood pressure and biochemical parameters over a 6‐week period. 2. Blood pressure was increased in all patients throughout the indomethacin treatment period (P<0.001) ‐ average mean blood pressure increases were 9 mmHg (casual), 8 mmHg (supine), 10 mmHg (standing). 3. The blood pressure increase during indomethacin treatment was independent of the particular antihypertensive regimen in use. 4. Plasma aldosterone concentration was reduced by 50% (P<0.01), plasma renin activity was reduced by 43% (P= 0.102) and plasma urea concentration was increased by 17% (P<0.001) during indomethacin treatment. 5. The findings confirm that indomethacin impairs the blood pressure lowering effect of antihypertensive regimens.

Original languageEnglish
Pages (from-to)537-541
Number of pages5
JournalClinical and Experimental Pharmacology and Physiology
Volume8
Issue number5
DOIs
Publication statusPublished - Sep 1981
Externally publishedYes

Keywords

  • aldosterone
  • antihypertensive agents
  • anti‐inflammatory agents
  • blood pressure
  • hypertension
  • indomethacin
  • prostaglandin synthase
  • prostaglandins
  • renin

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