TY - JOUR
T1 - The Effects of Long-term CPAP on Weight Change in Patients With Comorbid OSA and Cardiovascular Disease
T2 - Data From the SAVE Trial
AU - Ou, Qiong
AU - Chen, Baixin
AU - Loffler, Kelly A.
AU - Luo, Yuanming
AU - Zhang, Xilong
AU - Chen, Rui
AU - Wang, Qian
AU - Drager, Luciano F.
AU - Lorenzi-Filho, Geraldo
AU - Hlavac, Michael
AU - McArdle, Nigel
AU - Mukherjee, Sutapa
AU - Mediano, Olga
AU - Barbe, Ferran
AU - Anderson, Craig S.
AU - McEvoy, R. Doug
AU - Woodman, Richard J.
AU - SAVE investigators
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Background: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants. Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [–0.40 to 0.54]; P =.773) or female subjects (mean [95% CI] between-group difference, –0.14 kg [–0.37 to 0.09]; P =.233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P =.031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change. Trial Registry: ClinicalTrials.gov; No.: NCT00738179; URL: www.clinicaltrials.gov.
AB - Background: Although recent evidence suggests that OSA treatment may cause weight gain, the long-term effects of CPAP on weight are not well established. Methods: This study was a post hoc analysis of the Sleep Apnea Cardiovascular Endpoints (SAVE) study, a multicenter, randomized trial of CPAP plus standard care vs standard care alone in adults with a history of cardiac or cerebrovascular events and moderate to severe OSA. Participants with weight, BMI, and neck and waist circumferences measured at baseline and during follow-up were included. Linear mixed models were used to examine sex-specific temporal differences, and a sensitivity analysis compared high CPAP adherers (≥ 4 h per night) with propensity-matched control participants. Results: A total of 2,483 adults (1,248 in the CPAP group and 1,235 in the control group) were included (mean 6.1 ± 1.5 measures of weight available). After a mean follow-up of 3.78 years, there was no difference in weight change between the CPAP and control groups, for male subjects (mean [95% CI] between-group difference, 0.07 kg [–0.40 to 0.54]; P =.773) or female subjects (mean [95% CI] between-group difference, –0.14 kg [–0.37 to 0.09]; P =.233). Similarly, there were no significant differences in BMI or other anthropometric measures. Although male participants who used CPAP ≥ 4 h per night gained slightly more weight than matched male control subjects without CPAP (mean difference, 0.38 kg [95% CI, 0.04 to 0.73]; P =.031), there were no between-group differences in other anthropometric variables, nor were there any differences between female high CPAP adherers and matched control subjects. Conclusions: Long-term CPAP use in patients with comorbid OSA and cardiovascular disease does not result in clinically significant weight change. Trial Registry: ClinicalTrials.gov; No.: NCT00738179; URL: www.clinicaltrials.gov.
KW - CPAP
KW - long-term
KW - OSA
KW - weight
UR - http://www.scopus.com/inward/record.url?scp=85060079339&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1006501
UR - http://purl.org/au-research/grants/NHMRC/1060078
UR - http://purl.org/au-research/grants/NHMRC/343020
U2 - 10.1016/j.chest.2018.08.1082
DO - 10.1016/j.chest.2018.08.1082
M3 - Article
C2 - 30268694
AN - SCOPUS:85060079339
SN - 0012-3692
VL - 155
SP - 720
EP - 729
JO - Chest
JF - Chest
IS - 4
ER -