The ENHANCES study: a randomised controlled trial of a nurse-led survivorship intervention for patients treated for head and neck cancer

Jane Turner, Patsy Yates, Lizbeth Kenny, Louisa G. Gordon, Bryan Burmeister, Brett G.M. Hughes, Alexandra L. McCarthy, Chris Perry, Raymond J. Chan, Alana Paviour, Helen Skerman, Martin Batstone, Lisa Mackenzie

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Purpose: A randomised controlled trial was conducted to evaluate the effectiveness of a nurse-delivered Head and Neck Cancer Survivor Self-Management Care Plan (HNCP) for patients who had completed treatment for head and neck cancer (HNC). Methods: Ten oncology nurses were trained to deliver the HNCP. The HNCP consisted of one face-to-face hour-long meeting in which the patient’s treatment was recorded, as were contact details of health professionals involved in their care and follow-up schedules. Patients were guided to nominate up to three goals for their future well-being and assisted to devise an action plan to achieve these. The HNCP was given to the patient and a copy was forwarded to their primary care physician. One hundred and nine patients were randomised after definitive curative intent treatment, 36 to HNCP, 36 to receive information about survivorship, and 37 to usual care. The primary outcome, analysed by intention-to-treat, was change in quality of life measured by the FACT-H&N from baseline to 6-month follow-up. Results: Quality of life of all groups decreased at 3 months but was close to baseline at 6 months. Compared with the usual care group, the only statistically significant mean difference at 6 months was for the information group on the physical well-being domain (mean difference 0.4, 95% − 1.8, 2.6, p < 0.05). Conclusions: A single-session nurse-delivered intervention is insufficient to improve the quality of life in HNC survivors compared with usual care. Provision of detailed written information about HNC survivorship is associated with improved physical well-being. Trial registration: ACTRN12613000542796.

Original languageEnglish
Pages (from-to)4627-4637
Number of pages11
JournalSupportive Care in Cancer
Issue number12
Publication statusPublished - Dec 2019
Externally publishedYes


  • Head and neck cancer
  • Self-management
  • Survivorship


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