The Epidemiology of Staphylococcus aureus and Panton-Valentine Leucocidin (pvl) in Central Australia, 2006-2010

Saliya Hewagama, Tim Spelman, Mark Woolley, J McLeod, David Gordon, Lloyd Einsiedel

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    10 Citations (Scopus)

    Abstract

    Background: The Central Australian Indigenous population has a high incidence of Staphylococcus aureus bacteremia (SAB) but little is known about the local molecular epidemiology. Methods: Prospective observational study of bacteremic and nasal colonizing S.aureus isolates between June 2006 to June 2010. All isolates underwent single nucleotide polymorphism (SNP) genotyping and testing for the presence of the Panton-Valentine Leucocidin (pvl) gene. Results: Invasive isolates (n=97) were predominantly ST93 (26.6%) and pvl positive (54.3%), which was associated with skin and soft tissue infections (OR 4.35, 95% CI 1.16, 16.31). Non-multiresistant MRSA accounted for 31.9% of bacteremic samples and showed a trend to being healthcare associated (OR 2.16, 95% CI 0.86, 5.40). Non-invasive isolates (n=54) were rarely ST93 (1.9%) or pvl positive (7.4%). Conclusions: In Central Australia, ST93 was the dominant S.aureus clone, and was frequently pvl positive and associated with an aggressive clinical phenotype. Whether non-nasal carriage is more important with invasive clones or whether colonization occurs only transiently remains to be elucidated.

    Original languageEnglish
    Article number382
    Pages (from-to)382-387
    Number of pages6
    JournalBMC Infectious Diseases
    Volume16
    Issue number1
    DOIs
    Publication statusPublished - 2016

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