The formation of proximate carcinogens from three polycyclic aromatic compounds by human liver microsomes

Sugiyanto, C. E. Scharping, M. E. Mcmanus, D. J. Birkett, G. M. Holder, A. J. Ryan

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    8 Citations (Scopus)

    Abstract

    1. The metabolism of 3H-benzo[a]pyrene (BP), 3H-7-methylbenz[c]acridine (7MBAC) and 3H-dibenz[a, j]acridine (DBAJAC) have been studied in human liver microsomes from 13 subjects. 2. When the metabolism of these carcinogens to more polar ethyl acetate-soluble metabolites were compared, the activities towards the nitrogenous careinogens were twice that determined for BP. 3. The specific rates of formation of the three proximate carcinogens, BP-7,8-dihydrodiol, 7MBAC-3,4-dihydrodiol and DBAJAC-3,4-dihydrodiol per nmol cytochrome P-450 for 12 subjects were positively correlated. 4. These dihydrodiols constituted 5.9±0.7%mean±SEM), 57.8±2.6% and 3.0±0.4% of the total metabolites identified by cochromatography with standards, 7MBAC, DBAJAC and BP respectively.

    Original languageEnglish
    Pages (from-to)1299-1307
    Number of pages9
    JournalXenobiotica
    Volume22
    Issue number11
    DOIs
    Publication statusPublished - 1992

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