The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

Jesslyn Saw, David Curtis, Damian Hussey, Alexander Dobrovic, Peter Aplan, Christopher Slape

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    NUP98 is among the most promiscuously translocated genes in hematological diseases. Among the 28 known fusion partners, there are two categories: homeobox genes and non-homeobox genes. The homeobox fusion partners are well-studied in animal models, resulting in HoxA cluster overexpression and hematological disease. The non-homeobox fusion partners are less well studied. We created transgenic animal models for three NUP98 fusion genes (one homeobox, two non-homeobox), and show that in this system, the NUP98-homeobox fusion promotes self-renewal and aberrant gene expression to a significantly greater extent. We conclude that homeobox partners create more potent NUP98 fusion oncogenes than do non-homeobox partners.

    Original languageEnglish
    Pages (from-to)1668-1673
    Number of pages6
    JournalLeukemia Research
    Volume37
    Issue number12
    DOIs
    Publication statusPublished - Dec 2013

    Keywords

    • Homeobox
    • HOX
    • Leukemia
    • NUP98
    • Translocation

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