The gut microbiome regulates host glucose homeostasis via peripheral serotonin

Alyce M. Martin; Julian M. Yabut; Jocelyn M. Choo; Amanda J. Page; Emily W. Sun; Claire F. Jessup; Steve L. Wesselingh; Waliul I. Khan; Geraint B. Rogers; Gregory R. Steinberg; Damien J. Keating

doi:10.1073/pnas.1909311116

The gut microbiome regulates host glucose homeostasis via peripheral serotonin

Alyce M. Martin, Julian M. Yabut, Jocelyn M. Choo, Amanda J. Page, Emily W. Sun, Claire F. Jessup, Steve L. Wesselingh, Waliul I. Khan, Geraint B. Rogers, Gregory R. Steinberg, Damien J. Keating

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

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Abstract

The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. Using both pharmacological inhibition and genetic deletion of gut-derived serotonin synthesis, we find that the improvements in host glucose handling caused by antibiotic-induced changes in microbiota composition are dependent on the synthesis of peripheral serotonin.

Original language	English
Pages (from-to)	19802-19804
Number of pages	3
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	116
Issue number	40
DOIs	https://doi.org/10.1073/pnas.1909311116
Publication status	Published - 1 Oct 2019

Bibliographical note

Keywords

Glucose homeostasis
Microbe−host interactions
Microbiome
Serotonin

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10.1073/pnas.1909311116Licence: CC BY-NC-ND

19802.fullFinal published version, 781 KBLicence: CC BY-NC-ND

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Martin, A. M., Yabut, J. M., Choo, J. M., Page, A. J., Sun, E. W., Jessup, C. F., Wesselingh, S. L., Khan, W. I., Rogers, G. B., Steinberg, G. R., & Keating, D. J. (2019). The gut microbiome regulates host glucose homeostasis via peripheral serotonin. Proceedings of the National Academy of Sciences of the United States of America, 116(40), 19802-19804. https://doi.org/10.1073/pnas.1909311116

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abstract = "The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. Using both pharmacological inhibition and genetic deletion of gut-derived serotonin synthesis, we find that the improvements in host glucose handling caused by antibiotic-induced changes in microbiota composition are dependent on the synthesis of peripheral serotonin.",

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author = "Martin, {Alyce M.} and Yabut, {Julian M.} and Choo, {Jocelyn M.} and Page, {Amanda J.} and Sun, {Emily W.} and Jessup, {Claire F.} and Wesselingh, {Steve L.} and Khan, {Waliul I.} and Rogers, {Geraint B.} and Steinberg, {Gregory R.} and Keating, {Damien J.}",

note = "'Copyright {\textcopyright} 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).'",

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doi = "10.1073/pnas.1909311116",

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Martin, AM, Yabut, JM, Choo, JM, Page, AJ, Sun, EW, Jessup, CF , Wesselingh, SL, Khan, WI, Rogers, GB, Steinberg, GR & Keating, DJ 2019, 'The gut microbiome regulates host glucose homeostasis via peripheral serotonin', Proceedings of the National Academy of Sciences of the United States of America, vol. 116, no. 40, pp. 19802-19804. https://doi.org/10.1073/pnas.1909311116

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AU - Jessup, Claire F.

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The gut microbiome regulates host glucose homeostasis via peripheral serotonin

Abstract

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Keywords

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