The gut microbiome regulates host glucose homeostasis via peripheral serotonin

Alyce M. Martin, Julian M. Yabut, Jocelyn M. Choo, Amanda J. Page, Emily W. Sun, Claire F. Jessup, Steve L. Wesselingh, Waliul I. Khan, Geraint B. Rogers, Gregory R. Steinberg, Damien J. Keating

Research output: Contribution to journalArticlepeer-review

87 Citations (Scopus)
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The gut microbiome is an established regulator of aspects of host metabolism, such as glucose handling. Despite the known impacts of the gut microbiota on host glucose homeostasis, the underlying mechanisms are unknown. The gut microbiome is also a potent mediator of gut-derived serotonin synthesis, and this peripheral source of serotonin is itself a regulator of glucose homeostasis. Here, we determined whether the gut microbiome influences glucose homeostasis through effects on gut-derived serotonin. Using both pharmacological inhibition and genetic deletion of gut-derived serotonin synthesis, we find that the improvements in host glucose handling caused by antibiotic-induced changes in microbiota composition are dependent on the synthesis of peripheral serotonin.

Original languageEnglish
Pages (from-to)19802-19804
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number40
Publication statusPublished - 1 Oct 2019

Bibliographical note

'Copyright © 2019 the Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).'


  • Glucose homeostasis
  • Microbe−host interactions
  • Microbiome
  • Serotonin


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