The history of prion disease

Francesco M. Galassi; Maciej Henneberg; Frank J. Rühli

doi:10.1016/S1474-4422(16)30252-6

The history of prion disease

Francesco M. Galassi, Maciej Henneberg, Frank J. Rühli

College of Humanities, Arts and Social Sciences

Research output: Contribution to journal › Comment/debate

Abstract

Prion diseases are fatal spongiform neurodegenerative pathologies caused by the mutant protein PrPSc, that propagates by changing the conformation of its physiological counterpart PrPC. Since Gajdusek's first description of kuru in 1957 and Prusiner's 1982 prion hypothesis, evidence has accumulated on the pathogenesis of prion diseases. However, the role of PrPC was only described in 2016: long-term preservation of neuronal integrity through an interaction with a yet unidentified Schwann cell receptor...

Original language	English
Pages (from-to)	1211
Number of pages	1
Journal	The Lancet Neurology
Volume	15
Issue number	12
DOIs	https://doi.org/10.1016/S1474-4422(16)30252-6
Publication status	Published - 1 Nov 2016

Keywords

Prion diseases
neurodegenerative pathologies
mutant protein

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abstract = "Prion diseases are fatal spongiform neurodegenerative pathologies caused by the mutant protein PrPSc, that propagates by changing the conformation of its physiological counterpart PrPC. Since Gajdusek's first description of kuru in 1957 and Prusiner's 1982 prion hypothesis, evidence has accumulated on the pathogenesis of prion diseases. However, the role of PrPC was only described in 2016: long-term preservation of neuronal integrity through an interaction with a yet unidentified Schwann cell receptor...",

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The history of prion disease

Abstract

Keywords

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