The host response in experimental corneal xenotransplantation

D. F.P. Larkin, K. A. Williams

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

In addressing the worldwide shortage of human donor cornea for transplantation, animal cornea may be a substitute if mechanisms of xenogeneic (cross-species) rejection can be identified and controlled. Xenotrans-plantation of solid organs is followed byhyperacute rejection within minutes due to humoral graft rejection. In an experimental model corneal xenografts in rats survived for 2-3 days, depending on the phylogenetic disparity of the donor animal. Endothelial injury was the specific cause of graft failure, probably mediated by humoral rejection mechanisms. A later cell-mediated rejection response was seen. The potent humoral response is the most important feature differentiating xenograft from allograft rejection.

Original languageEnglish
Pages (from-to)254-260
Number of pages7
JournalEye
Volume9
Issue number2
DOIs
Publication statusPublished - 1 Mar 1995
Externally publishedYes

Keywords

  • Cornea
  • Corticosteroids
  • Immunosuppression
  • Rejection

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