The human enteric nervous system. Historical and modern advances. Collaboration between science and surgery

David A. Wattchow, David Smolilo, Tim Hibberd, Nick J. Spencer, Simon J.H. Brookes, Roberto De Giorgio, Paul T. Heitmann, Marcello Costa, Phil G. Dinning

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Background: There are considerable advantages and opportunities for surgeons and trainee surgeons in conducting a period of research allied with basic scientists. Such clinicians are well placed to define relevant clinical questions, provide human material (tissue, biopsy and blood) and translate the techniques derived in experimental animals to human subjects. Methods: This small review explores research conducted on the nervous system of the intestines, with an emphasis on the translation of findings from animal to human. Results: This work shows that new techniques of immunohistochemistry and retrograde tracing, developed in animal tissue, have greatly expanded our knowledge of the structure of the human enteric nervous system. Conclusions: Such findings have sparked therapeutic trials for the treatment of gastrointestinal disorders in patients.

Original languageEnglish
Pages (from-to)1365-1370
Number of pages6
JournalANZ Journal of Surgery
Volume92
Issue number6
Early online date11 Apr 2022
DOIs
Publication statusPublished - Jun 2022

Keywords

  • colon
  • enteric nervous system
  • neural pathways

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