The human leucocyte P30 antigen: properties and assessment of value as a clonal marker

H. Zola; H. A. Moore; I. K. Hunter; A. Hohmann; P. J. Mcnamara; J. Bradley; P. Mum; A. Morley; J. V. Melo; D. Catovsky

doi:10.1111/j.1399-0039.1985.tb00935.x

The human leucocyte P30 antigen: properties and assessment of value as a clonal marker

H. Zola, H. A. Moore, I. K. Hunter, A. Hohmann, P. J. Mcnamara, J. Bradley, P. Mum, A. Morley, J. V. Melo, D. Catovsky

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Abstract

FMC3 and FMC29 are monoclonal antibodies which react with a 30,000 Dalton molecule expressed on the lymphocyte surface membrane. The molecule is a protein which does not appear to be N‐glycosylated. The antigen, which is also expressed intracellularly, does not appear to be a marker of differentiation or maturation. Polyclonal cell populations, such as peripheral blood lymphocytes, show a bimodal distribution of surface antigen density, whilst monoclonal cell populations analysed quantitatively showed unimodal antigen density distributions. This suggests the antigen may be a clonal marker.

Original language	English
Pages (from-to)	60-70
Number of pages	11
Journal	Tissue Antigens
Volume	26
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0039.1985.tb00935.x
Publication status	Published - Jul 1985
Externally published	Yes

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title = "The human leucocyte P30 antigen: properties and assessment of value as a clonal marker",

abstract = "FMC3 and FMC29 are monoclonal antibodies which react with a 30,000 Dalton molecule expressed on the lymphocyte surface membrane. The molecule is a protein which does not appear to be N‐glycosylated. The antigen, which is also expressed intracellularly, does not appear to be a marker of differentiation or maturation. Polyclonal cell populations, such as peripheral blood lymphocytes, show a bimodal distribution of surface antigen density, whilst monoclonal cell populations analysed quantitatively showed unimodal antigen density distributions. This suggests the antigen may be a clonal marker.",

author = "H. Zola and Moore, {H. A.} and Hunter, {I. K.} and A. Hohmann and Mcnamara, {P. J.} and J. Bradley and P. Mum and A. Morley and Melo, {J. V.} and D. Catovsky",

year = "1985",

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doi = "10.1111/j.1399-0039.1985.tb00935.x",

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T1 - The human leucocyte P30 antigen

T2 - properties and assessment of value as a clonal marker

AU - Zola, H.

AU - Moore, H. A.

AU - Hunter, I. K.

AU - Hohmann, A.

AU - Mcnamara, P. J.

AU - Bradley, J.

AU - Mum, P.

AU - Morley, A.

AU - Melo, J. V.

AU - Catovsky, D.

PY - 1985/7

Y1 - 1985/7

N2 - FMC3 and FMC29 are monoclonal antibodies which react with a 30,000 Dalton molecule expressed on the lymphocyte surface membrane. The molecule is a protein which does not appear to be N‐glycosylated. The antigen, which is also expressed intracellularly, does not appear to be a marker of differentiation or maturation. Polyclonal cell populations, such as peripheral blood lymphocytes, show a bimodal distribution of surface antigen density, whilst monoclonal cell populations analysed quantitatively showed unimodal antigen density distributions. This suggests the antigen may be a clonal marker.

AB - FMC3 and FMC29 are monoclonal antibodies which react with a 30,000 Dalton molecule expressed on the lymphocyte surface membrane. The molecule is a protein which does not appear to be N‐glycosylated. The antigen, which is also expressed intracellularly, does not appear to be a marker of differentiation or maturation. Polyclonal cell populations, such as peripheral blood lymphocytes, show a bimodal distribution of surface antigen density, whilst monoclonal cell populations analysed quantitatively showed unimodal antigen density distributions. This suggests the antigen may be a clonal marker.

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VL - 26

SP - 60

EP - 70

JO - Tissue Antigens

JF - Tissue Antigens

IS - 1

ER -

The human leucocyte P30 antigen: properties and assessment of value as a clonal marker

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