The immunohistochemical distribution of neuropeptide Y in lumbar pre- and paravertebral sympathetic ganglia of the guinea pig

Elspeth M. McLachlan, Ida J. Llewellyn-Smith

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48 Citations (Scopus)

Abstract

Neuropeptide Y (NPY)- like immunoreactive nerve cell bodies and nerve fibres have been studied in normal and colchicine-treated ganglia of the caudal lumbar sympathetic chain (LSC) and the inferior mesenteric ganglion (IMG) of the guinea pig. The great majority of noradrenergic ganglion cells in the LSC (defined as containing tyrosine hydroxylase immunoreactivity), but less than 20% of those in the IMG, were NPY-positive. These proportions correspond well to the proportions of neurones that have been found to discharge phasically in electrophysiological experiments on the same ganglia. As noradrenergic terminals innervating blood vessels contain NPY, the data are consistent with the idea that phasic discharge is a characteristic of vasoconstrictor neurones.

Original languageEnglish
Pages (from-to)313-324
Number of pages12
JournalJournal of the Autonomic Nervous System
Volume17
Issue number4
DOIs
Publication statusPublished - 1 Dec 1986
Externally publishedYes

Keywords

  • Colon innervation
  • Inferior mesenteric ganglion
  • Noradrenergic ganglion cell
  • Pelvic innervation
  • Vasoconstrictor neurone

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