The Impact of Addictive Drugs on HIV Immunopathogenesis

Xiaochun Li, Wenwen He, Yifang Wen, Binhua Ling, Lishomwa C. Ndhlovu, Amanda Wagner, Azizul Haque, Jingjing Wang, Danielle Macedo, Ren Lang, Aimee McRae-Clark, Lei Huang, Wei Jiang, Davide Amato

Research output: Contribution to journalReview articlepeer-review

Abstract

Substance Use Disorder (SUD) is associated with neurocognitive disorders as well as with alterations of the immune system function. Different addictive drugs exhibit differences in neurocognitive performance and immune response against inflammation. In HIV disease, SUD is associated with increased HIV susceptibility and infection, HIV replication, blunted CD4+ T cell reconstitution under viral suppressive Antiretroviral Therapy (ART), perturbations of immune system and accelerated HIV-associated neurologic disorders (HAND). To date, extensive studies have been done to understand high incidence of HAND in HIV disease, but the exact mechanisms are not completely understood, especially of long term ART and viral suppression settings. We have reviewed work on the impact of addictive drugs on HAND in HIV immunopathogenesis.

Original languageEnglish
Article number236145
Number of pages8
JournalJournal of Drug and Alcohol Research
Volume10
Issue number11
Publication statusPublished - 30 Nov 2021

Keywords

  • Antiretroviral therapy
  • CD4 T cells
  • HAND
  • HIV
  • Neurocognition
  • Substance use disorder

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