The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation

Shaheen Hasmat; Gillian Heller; Lachlan Cook; Ruta Gupta; Jonathan R. Clark; Eng H. Ooi; Tsu Hui Low

doi:10.1002/hed.27485

The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation

Shaheen Hasmat, Gillian Heller, Lachlan Cook, Ruta Gupta, Jonathan R. Clark, Eng H. Ooi, Tsu Hui Low

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Background: Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients.

Methods: Patients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease-specific survival (DSS) and overall survival (OS).

Results: Complete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11–2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01–1.73, p = 0.045).

Conclusions: Multifocal PNI is a significant predictor of survival in OSCC.

Original language	English
Pages (from-to)	2605-2612
Number of pages	8
Journal	Head & Neck
Volume	45
Issue number	10
Early online date	10 Aug 2023
DOIs	https://doi.org/10.1002/hed.27485
Publication status	Published - Oct 2023

Keywords

AJCC
oral cancer
perineural invasion
squamous cell carcinoma
survival

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation",

abstract = "Background: Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients. Methods: Patients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease-specific survival (DSS) and overall survival (OS). Results: Complete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11–2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01–1.73, p = 0.045). Conclusions: Multifocal PNI is a significant predictor of survival in OSCC.",

keywords = "AJCC, oral cancer, perineural invasion, squamous cell carcinoma, survival",

author = "Shaheen Hasmat and Gillian Heller and Lachlan Cook and Ruta Gupta and Clark, {Jonathan R.} and Ooi, {Eng H.} and Low, {Tsu Hui}",

year = "2023",

month = oct,

doi = "10.1002/hed.27485",

language = "English",

volume = "45",

pages = "2605--2612",

journal = "Head & Neck",

issn = "1043-3074",

publisher = "John Wiley & Sons, Inc",

number = "10",

}

TY - JOUR

T1 - The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma

T2 - A multicenter investigation

AU - Hasmat, Shaheen

AU - Heller, Gillian

AU - Cook, Lachlan

AU - Gupta, Ruta

AU - Clark, Jonathan R.

AU - Ooi, Eng H.

AU - Low, Tsu Hui

PY - 2023/10

Y1 - 2023/10

N2 - Background: Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients. Methods: Patients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease-specific survival (DSS) and overall survival (OS). Results: Complete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11–2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01–1.73, p = 0.045). Conclusions: Multifocal PNI is a significant predictor of survival in OSCC.

AB - Background: Perineural invasion (PNI) in oral squamous cell carcinoma (OSCC) does not contribute to the current American Joint Committee on Cancer 8th edition (AJCC8) staging manual. This study seeks to validate the effect of multifocal PNI in a large cohort of patients. Methods: Patients undergoing primary surgical treatment of OSCC with curative intent between 1995 and 2022 was retrieved from two Australian head and neck databases. PNI was categorized as a single focus or multiple foci. Study end points included disease-specific survival (DSS) and overall survival (OS). Results: Complete data for survival analysis was available in 993 patients. Multifocal PNI was associated with a 61% increased risk of death due to OSCC (HR 1.61, 95% CI 1.11–2.33, p = 0.014) and a 32% increased risk of death from any cause (HR 1.32, 95% CI 1.01–1.73, p = 0.045). Conclusions: Multifocal PNI is a significant predictor of survival in OSCC.

KW - AJCC

KW - oral cancer

KW - perineural invasion

KW - squamous cell carcinoma

KW - survival

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U2 - 10.1002/hed.27485

DO - 10.1002/hed.27485

M3 - Article

AN - SCOPUS:85167610301

SN - 1043-3074

VL - 45

SP - 2605

EP - 2612

JO - Head & Neck

JF - Head & Neck

IS - 10

ER -

The impact of multifocal perineural invasion in predicting survival in patients with oral squamous cell carcinoma: A multicenter investigation

Abstract

Keywords

UN SDGs

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