The Importance of High-Quality Evidence of the Long-Term Impact of Nonfatal Events Used in Randomized Controlled Trials: A Case Study of Prasugrel

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    Abstract

    Randomized controlled trials (RCTs) are the centerpiece of evidence-based medicine. However, because of the limited follow-up, additional evidence on the long-term consequences of the outcomes used in trials is commonly required for clinical and policy decision making. This article provides insights into the importance and challenges of using such evidence through the case study of nonfatal myocardial infarction (MI) and nonfatal bleeding with prasugrel.

    Original languageEnglish
    Pages (from-to)27-29
    Number of pages3
    JournalClinical Pharmacology and Therapeutics
    Volume90
    Issue number1
    DOIs
    Publication statusPublished - Jul 2011

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