The Importance of High-Quality Evidence of the Long-Term Impact of Nonfatal Events Used in Randomized Controlled Trials: A Case Study of Prasugrel

C Lu; Jonathan Karnon; Michael Sorich

doi:10.1038/clpt.2011.61

The Importance of High-Quality Evidence of the Long-Term Impact of Nonfatal Events Used in Randomized Controlled Trials: A Case Study of Prasugrel

C Lu, Jonathan Karnon, Michael Sorich

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Randomized controlled trials (RCTs) are the centerpiece of evidence-based medicine. However, because of the limited follow-up, additional evidence on the long-term consequences of the outcomes used in trials is commonly required for clinical and policy decision making. This article provides insights into the importance and challenges of using such evidence through the case study of nonfatal myocardial infarction (MI) and nonfatal bleeding with prasugrel.

Original language	English
Pages (from-to)	27-29
Number of pages	3
Journal	Clinical Pharmacology and Therapeutics
Volume	90
Issue number	1
DOIs	https://doi.org/10.1038/clpt.2011.61
Publication status	Published - Jul 2011

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10.1038/clpt.2011.61

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The Importance of High-Quality Evidence of the Long-Term Impact of Nonfatal Events Used in Randomized Controlled Trials: A Case Study of Prasugrel

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