The ineffectiveness of coumarin treatment on thermal oedema of macrophage free rats

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The administration of silica prevents coumarin stimulated lysis of accumulated abnormal protein. This impairs the resolution of thermal (burn) edema which is normally increased with coumarin administration. Evidence suggests that there is a rapid differentiation and infiltration of monocytes into the tissues and that these are selectively retained. This is aided by coumarin which increases tissue permeability. Coumarin also injures the vascular endothelium of some vessels, allowing extra protein and fluid into the tissues. Death of recently differentiated macrophages and subsequent release of their lysosomal contents into the extracellular spaces may be responsible for the changes in serum enzyme levels. It would seem that macrophages are the only cells in which coumarin stimulates increased phagocytosis, enzyme producton and proteolysis.

Original languageEnglish
Pages (from-to)170-178
Number of pages9
JournalBritish Journal of Experimental Pathology
Volume57
Issue number2
Publication statusPublished - 1976
Externally publishedYes

Fingerprint Dive into the research topics of 'The ineffectiveness of coumarin treatment on thermal oedema of macrophage free rats'. Together they form a unique fingerprint.

Cite this