TY - JOUR
T1 - The Infectious Uveitis Treatment Algorithm Network (TITAN) Report 1—global current practice patterns for the management of Herpes Simplex Virus and Varicella Zoster Virus anterior uveitis
AU - Thng, Zheng Xian
AU - Putera, Ikhwanuliman
AU - Testi, Ilaria
AU - Chan, Kevin
AU - Westcott, Mark
AU - Chee, Soon Phaik
AU - Dick, Andrew D.
AU - Kempen, John H.
AU - Bodaghi, Bahram
AU - Thorne, Jennifer E.
AU - Barisani-Asenbauer, Talin
AU - de Smet, Marc D.
AU - Smith, Justine R.
AU - McCluskey, Peter
AU - La Distia Nora, Rina
AU - Jabs, Douglas A.
AU - de Boer, Joke H.
AU - Sen, H. Nida
AU - Goldstein, Debra A.
AU - Khairallah, Moncef
AU - Davis, Janet L.
AU - Rosenbaum, James T.
AU - Jones, Nicholas P.
AU - Nguyen, Quan Dong
AU - Pavesio, Carlos
AU - Agrawal, Rupesh
AU - Gupta, Vishali
AU - on behalf of TITAN consensus guidelines group
AU - Zierhut, Manfred
AU - Palestine, Alan
AU - Denniston, Alastair K.
AU - Invernizzi, Alessandro
AU - Radgonde, Amer
AU - Kumar, Amitabh
AU - Curi, Andre
AU - Agarwal, Aniruddha
AU - Yee, Anita Chan Sook
AU - Okada, Annabelle A.
AU - Schlaen, Ariel
AU - Heiligenhaus, Arnd
AU - Gurbaxani, Avinash
AU - Murugan, S. Bala
AU - Lee, Cecilia S.
AU - Das, Dipankar
AU - Baglivo, Edoardo
AU - Carreño, Ester
AU - Arevalo, J. Fernando
AU - Pichi, Francesco
AU - Uy, Harvey
AU - Al-Dhibi, Hassan A.
AU - Garweg, Justus G.
AU - Biswas, Jyotirmay
AU - Murthy, Kalpana Babu
AU - Caspers, Laure
AU - Cimino, Luca
AU - Lim, Lyndell L.
AU - de la Maza, Maite Sainz
AU - Agarwal, Mamta
AU - Mochizucki, Manabu
AU - Agarwal, Manisha
AU - Munk, Marion R.
AU - Accorinti, Massimo
AU - Tyagi, Mudit
AU - Acharya, Nisha
AU - Mahendradas, Padmamalini
AU - Majumder, Parthopratim Dutta
AU - Murray, Philip I.
AU - Lin, Phoebe
AU - Neri, Piergiorgio
AU - Bansal, Reema
AU - Read, Russell W.
AU - Mehta, Salil
AU - Shawki, Samir S.Shoughy
AU - Mazumdar, Shahana
AU - Narain, Shishir
AU - Androudi, Sofia
AU - Murthy, Somasheila
AU - Rathinam, S. R.
AU - Beng, Stephen Teoh Charn
AU - Sridharan, Sudharshan
AU - Phatak, Sumita
AU - Tappeiner, Christoph
AU - Lai, Timothy Y.Y.
AU - Yuen, Yew Sen
AU - Feng, Yun
PY - 2024/1
Y1 - 2024/1
N2 - Aims: To present current expert practice patterns and to formulate a consensus for the management of HSV and VZV AU by uveitis specialists worldwide. Methods: A two-round online modified Delphi survey with masking of the study team was conducted. Responses were collected from 76 international uveitis experts from 21 countries. Current practices in the diagnosis and treatment of HSV and VZV AU were identified. A working group (The Infectious Uveitis Treatment Algorithm Network [TITAN]) developed data into consensus guidelines. Consensus is defined as a particular response towards a specific question meeting ≥75% of agreement or IQR ≤ 1 when a Likert scale is used. Results: Unilaterality, increased intraocular pressure (IOP), decreased corneal sensation and diffuse or sectoral iris atrophy are quite specific for HSV or VZV AU from consensus opinion. Sectoral iris atrophy is characteristic of HSV AU. Treatment initiation is highly variable, but most experts preferred valacyclovir owing to simpler dosing. Topical corticosteroids and beta-blockers should be used if necessary. Resolution of inflammation and normalisation of IOP are clinical endpoints. Conclusions: Consensus was reached on several aspects of diagnosis, choice of initial treatment, and treatment endpoints for HSV and VZV AU. Treatment duration and management of recurrences varied between experts.
AB - Aims: To present current expert practice patterns and to formulate a consensus for the management of HSV and VZV AU by uveitis specialists worldwide. Methods: A two-round online modified Delphi survey with masking of the study team was conducted. Responses were collected from 76 international uveitis experts from 21 countries. Current practices in the diagnosis and treatment of HSV and VZV AU were identified. A working group (The Infectious Uveitis Treatment Algorithm Network [TITAN]) developed data into consensus guidelines. Consensus is defined as a particular response towards a specific question meeting ≥75% of agreement or IQR ≤ 1 when a Likert scale is used. Results: Unilaterality, increased intraocular pressure (IOP), decreased corneal sensation and diffuse or sectoral iris atrophy are quite specific for HSV or VZV AU from consensus opinion. Sectoral iris atrophy is characteristic of HSV AU. Treatment initiation is highly variable, but most experts preferred valacyclovir owing to simpler dosing. Topical corticosteroids and beta-blockers should be used if necessary. Resolution of inflammation and normalisation of IOP are clinical endpoints. Conclusions: Consensus was reached on several aspects of diagnosis, choice of initial treatment, and treatment endpoints for HSV and VZV AU. Treatment duration and management of recurrences varied between experts.
KW - Education
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=85181528671&partnerID=8YFLogxK
U2 - 10.1038/s41433-023-02630-9
DO - 10.1038/s41433-023-02630-9
M3 - Article
C2 - 37419957
AN - SCOPUS:85181528671
SN - 0950-222X
VL - 38
SP - 61
EP - 67
JO - Eye (Basingstoke)
JF - Eye (Basingstoke)
IS - 1
ER -