The influence of coumarin on blood levels of radio labelled protein and radio labelled poly-vinyl-pyrrolidone in thermally injured rats

N. B. Piller

doi:10.1007/BF01851314

The influence of coumarin on blood levels of radio labelled protein and radio labelled poly-vinyl-pyrrolidone in thermally injured rats

N. B. Piller

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

The evidence presented in this paper suggests that coumarin is a RES stimulator. An enhanced removal of both RPP and radio RPVP was observed beginning at or before 30 minutes and lasting up to 6 hours. Over this time, RPP removal was enhanced by an average of 40%, while RPVP removal was enhanced by 60%. Since RPVP is non-metbabolizable, its levels may be a more accurate estimate of the stimulatory effect of coumarin. This evidence fits in well previous results which have suggested that coumarin may increase the numer of phagocytic cells. Other results have shown enhancement of protein lysis by 74% over similar periods, while enhanced protease activity levels of 50% have been observed to accompany this.

Original language	English
Pages (from-to)	165-172
Number of pages	8
Journal	Research in Experimental Medicine
Volume	168
DOIs	https://doi.org/10.1007/BF01851314
Publication status	Published - Oct 1976
Externally published	Yes

Keywords

Coumarin
reticulo-endothelial system stimulator
thermal injury
tracer removal

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title = "The influence of coumarin on blood levels of radio labelled protein and radio labelled poly-vinyl-pyrrolidone in thermally injured rats",

abstract = "The evidence presented in this paper suggests that coumarin is a RES stimulator. An enhanced removal of both RPP and radio RPVP was observed beginning at or before 30 minutes and lasting up to 6 hours. Over this time, RPP removal was enhanced by an average of 40%, while RPVP removal was enhanced by 60%. Since RPVP is non-metbabolizable, its levels may be a more accurate estimate of the stimulatory effect of coumarin. This evidence fits in well previous results which have suggested that coumarin may increase the numer of phagocytic cells. Other results have shown enhancement of protein lysis by 74% over similar periods, while enhanced protease activity levels of 50% have been observed to accompany this.",

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N2 - The evidence presented in this paper suggests that coumarin is a RES stimulator. An enhanced removal of both RPP and radio RPVP was observed beginning at or before 30 minutes and lasting up to 6 hours. Over this time, RPP removal was enhanced by an average of 40%, while RPVP removal was enhanced by 60%. Since RPVP is non-metbabolizable, its levels may be a more accurate estimate of the stimulatory effect of coumarin. This evidence fits in well previous results which have suggested that coumarin may increase the numer of phagocytic cells. Other results have shown enhancement of protein lysis by 74% over similar periods, while enhanced protease activity levels of 50% have been observed to accompany this.

AB - The evidence presented in this paper suggests that coumarin is a RES stimulator. An enhanced removal of both RPP and radio RPVP was observed beginning at or before 30 minutes and lasting up to 6 hours. Over this time, RPP removal was enhanced by an average of 40%, while RPVP removal was enhanced by 60%. Since RPVP is non-metbabolizable, its levels may be a more accurate estimate of the stimulatory effect of coumarin. This evidence fits in well previous results which have suggested that coumarin may increase the numer of phagocytic cells. Other results have shown enhancement of protein lysis by 74% over similar periods, while enhanced protease activity levels of 50% have been observed to accompany this.

KW - Coumarin

KW - reticulo-endothelial system stimulator

KW - thermal injury

KW - tracer removal

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DO - 10.1007/BF01851314

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SN - 0300-9130

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EP - 172

JO - Research in Experimental Medicine

JF - Research in Experimental Medicine

ER -

The influence of coumarin on blood levels of radio labelled protein and radio labelled poly-vinyl-pyrrolidone in thermally injured rats

Abstract

Keywords

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