TY - JOUR
T1 - The influence of early-life microbial exposures on long-term respiratory health
AU - Taylor, Steven L.
AU - Simpson, Jodie L.
AU - Rogers, Geraint B.
PY - 2021/12
Y1 - 2021/12
N2 - Host-microbiome interactions exert a profound influence on human physiology and health outcomes. In particular, certain characteristics of commensal microbiota during a critical period in early life are essential for the establishment of immune tone and metabolic control. An increasing body of evidence suggests that early life exposures that disrupt these interactions can substantially influence life-long risks for respiratory disease. Here, we explore how such early life exposures, including antibiotic exposure, maternal diet, preterm birth, mode of delivery, breastfeeding, and environmental variables shape the infant microbiome, and the mechanisms by such changes can in turn impact respiratory health.
AB - Host-microbiome interactions exert a profound influence on human physiology and health outcomes. In particular, certain characteristics of commensal microbiota during a critical period in early life are essential for the establishment of immune tone and metabolic control. An increasing body of evidence suggests that early life exposures that disrupt these interactions can substantially influence life-long risks for respiratory disease. Here, we explore how such early life exposures, including antibiotic exposure, maternal diet, preterm birth, mode of delivery, breastfeeding, and environmental variables shape the infant microbiome, and the mechanisms by such changes can in turn impact respiratory health.
KW - Anti-bacterial agents
KW - Asthma
KW - Chronic obstructive
KW - Hypersensitivity
KW - Infant
KW - Microbiota
KW - Premature birth
KW - Pulmonary disease
UR - http://www.scopus.com/inward/record.url?scp=85107914500&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/NHMRC/1155179
U2 - 10.1016/j.prrv.2021.05.003
DO - 10.1016/j.prrv.2021.05.003
M3 - Review article
AN - SCOPUS:85107914500
SN - 1526-0542
VL - 40
SP - 15
EP - 23
JO - Paediatric respiratory reviews
JF - Paediatric respiratory reviews
ER -