The influence of early-life microbial exposures on long-term respiratory health

Steven L. Taylor, Jodie L. Simpson, Geraint B. Rogers

Research output: Contribution to journalReview articlepeer-review


Host-microbiome interactions exert a profound influence on human physiology and health outcomes. In particular, certain characteristics of commensal microbiota during a critical period in early life are essential for the establishment of immune tone and metabolic control. An increasing body of evidence suggests that early life exposures that disrupt these interactions can substantially influence life-long risks for respiratory disease. Here, we explore how such early life exposures, including antibiotic exposure, maternal diet, preterm birth, mode of delivery, breastfeeding, and environmental variables shape the infant microbiome, and the mechanisms by such changes can in turn impact respiratory health.

Original languageEnglish
Number of pages9
JournalPaediatric respiratory reviews
Early online date26 May 2021
Publication statusE-pub ahead of print - 26 May 2021


  • Anti-bacterial agents
  • Asthma
  • Chronic obstructive
  • Hypersensitivity
  • Infant
  • Microbiota
  • Premature birth
  • Pulmonary disease


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