The influence of putrefaction and sample storage on post-mortem toxicology results.

Danielle Butzbach

    Research output: Contribution to journalReview articlepeer-review

    44 Citations (Scopus)

    Abstract

    There are numerous biochemical and biological processes that occur after death that may have a significant influence on post-mortem drug concentrations. These processes may render the quantification of particular drugs unreliable, or even result in drugs being undetectable in some instances, despite the use of several methods. Problems may occur with changes in the drug concentration via bacterial degradation, residual tissue enzymatic activity, or via post-mortem redistribution from tissues of a higher to a lower concentration. Many analytical techniques can suffer from interferences due to co-extracted putrefactive compounds that mask or alter the way a drug is detected, depending on the analytical technique utilised. The following paper reviews problems associated with post-mortem drug concentration changes, and the significance of microbial influences during the post-mortem interval and sample storage.

    Original languageEnglish
    Pages (from-to)35-45
    Number of pages11
    JournalForensic Science, Medicine, and Pathology
    Volume6
    Issue number1
    DOIs
    Publication statusPublished - Mar 2010

    Keywords

    • Bacteria
    • Degradation
    • Drug stability
    • Putrefaction
    • Toxicology

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