The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts

Keryn Williams, T Kelly, Marie Lowe, Douglas Coster

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    We investigated whether a rejection episode in one graft was associated with rejection in the other graft, in recipients with bilateral corneal transplants. In a prospectively maintained, national register of 14 865 followed corneal grafts, 1476 patients with bilateral penetrating corneal grafts were identified. Occurrence of rejection was a risk factor for graft failure (p < 0.0001). Logistic regression was used to calculate the adjusted odds ratio for rejection in one eye following rejection in the other eye. In the subset of 1118 patients with bilateral grafts but no history of previous grafts or rejections in either eye, the adjusted odds ratio for a rejection episode in the first eye following rejection in the second was 3.27 (95% confidence interval, CI 1.85, 5.79; p < 0.001). The adjusted odds ratio was 2.04 (95% CI 1.07, 3.91; p = 0.03) for rejection in the second eye following rejection in the first. The median time between the first rejection episode in one eye and the first rejection episode in the other eye was 15 months. Patients with bilateral corneal grafts who suffer a graft rejection episode in one eye are at significantly greater odds of suffering a rejection episode in the other corneal transplant.

    Original languageEnglish
    Pages (from-to)921-930
    Number of pages10
    JournalAmerican Journal of Transplantation
    Volume10
    Issue number4
    DOIs
    Publication statusPublished - Apr 2010

    Keywords

    • Bilateral transplant
    • Corneal transplantation
    • Rejection risk

    Fingerprint Dive into the research topics of 'The Influence of Rejection Episodes in Recipients of Bilateral Corneal Grafts'. Together they form a unique fingerprint.

    Cite this