The influence of the renin angiotensin system on abnormal expression of nerve growth factor in the spontaneously hypertensive rat

S. Jeffreson, R. Rush, C. Zettler, D. B. Frewin, R. J. Head

    Research output: Contribution to journalArticle

    7 Citations (Scopus)

    Abstract

    1. The levels of the neurotrophic factor, nerve growth factor (NGF) in the mesenteric vascular bed of the spontaneously hypertensive rat (SHR) were greater than those in the corresponding vascular bed of normotensive Wistar‐Kyoto rats (WKY). 2. Administration of angiotensin II (200 ng/kg per min, by minipump) for 2 weeks to juvenile WKY rats increased the levels of NGF in the mesenteric vasculature to those seen in untreated SHR. 3. Administration of the angiotensin II receptor antagonists losartan (30 mg/kg per day, p.o.) or PD144277 (10 mg/kg per day, p.o.) to juvenile SHR for 4 weeks reduced the levels of NGF such that they were indistinguishable from the values obtained for normotensive WKY rats. 4. The results confirm the elevated level of NGF in the mesenteric vasculature of the SHR and suggest that angiotensin II may play a role in regulating the abnormal concentrations of the protein in this tissue.

    Original languageEnglish
    Pages (from-to)478-480
    Number of pages3
    JournalClinical and Experimental Pharmacology and Physiology
    Volume22
    Issue number6-7
    DOIs
    Publication statusPublished - Jul 1995

    Keywords

    • angiotensin II
    • mesenteric vascular bed
    • nerve growth factor, spontaneously hypertensive rat
    • Wistar‐Kyoto rat.

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