The interplay between size and valence state on the antibacterial activity of sub-10 nm silver nanoparticles

Hanif Haidari, Nirmal Goswami, Richard Bright, Zlatko Kopecki, Allison J. Cowin, Sanjay Garg, Krasimir Vasilev

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Silver nanoparticles (AgNPs) have attracted enormous interest because of their excellent antibacterial properties, low cytotoxicity and limited evidence for resistance. As a general trend, smaller nanoparticles are considered to have stronger antibacterial activity. In this work we investigate whether this trend is valid for the sub-10 nm region by designing and synthesising three types of sub-10 nm AgNPs (∼1.87, ∼2.93 and ∼6.53 nm) to reveal the influence of size, valence state and structure on the antibacterial potency of AgNPs. We found that NPs with a size of ∼2.93 nm having a high concentration of silver in the first valence state presented the highest bacterial killing potency as well as low cytotoxicity to mammalian cells. The new insights presented in this study open future avenues for the engineering of highly potent silver nanoantibiotics that can be incorporated into future advanced medical devices and therapies capable of protecting patients from infections.

Original languageEnglish
Pages (from-to)2365-2371
Number of pages7
JournalNanoscale Advances
Volume1
Issue number6
DOIs
Publication statusPublished - Jun 2019
Externally publishedYes

Keywords

  • antibacterial
  • silver nanoparticles
  • medical devices
  • cytotoxicity

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