The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Junxuan Peng, Zuchao Cai, Ruixue Zhao, Jiahao Chen, Guochao Liu, Chao Dong, David Lim, Zhihui Feng

Research output: Contribution to journalArticlepeer-review

Abstract

This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

Original languageEnglish
Pages (from-to)609-621
Number of pages13
JournalToxicology Research
Volume9
Issue number5
DOIs
Publication statusPublished - Sep 2020
Externally publishedYes

Keywords

  • Breast tumor
  • DMBA
  • Macrophage
  • Sema3c
  • Valproic acid (VPA)

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