Abstract
This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.
Original language | English |
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Pages (from-to) | 609-621 |
Number of pages | 13 |
Journal | Toxicology Research |
Volume | 9 |
Issue number | 5 |
DOIs | |
Publication status | Published - Sep 2020 |
Externally published | Yes |
Keywords
- Breast tumor
- DMBA
- Macrophage
- Sema3c
- Valproic acid (VPA)