The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Junxuan Peng; Zuchao Cai; Ruixue Zhao; Jiahao Chen; Guochao Liu; Chao Dong; David Lim; Zhihui Feng

doi:10.1093/TOXRES/TFAA069

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Junxuan Peng
, Zuchao Cai
, Ruixue Zhao
, Jiahao Chen
, Guochao Liu
, Chao Dong
, David Lim
, Zhihui Feng

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

Original language	English
Pages (from-to)	609-621
Number of pages	13
Journal	Toxicology Research
Volume	9
Issue number	5
DOIs	https://doi.org/10.1093/TOXRES/TFAA069
Publication status	Published - Sept 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast tumor
DMBA
Macrophage
Sema3c
Valproic acid (VPA)

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10.1093/TOXRES/TFAA069Licence: In Copyright

Cite this

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title = "The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs",

abstract = "This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.",

keywords = "Breast tumor, DMBA, Macrophage, Sema3c, Valproic acid (VPA)",

author = "Junxuan Peng and Zuchao Cai and Ruixue Zhao and Jiahao Chen and Guochao Liu and Chao Dong and David Lim and Zhihui Feng",

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doi = "10.1093/TOXRES/TFAA069",

language = "English",

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pages = "609--621",

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TY - JOUR

T1 - The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

AU - Peng, Junxuan

AU - Cai, Zuchao

AU - Zhao, Ruixue

AU - Chen, Jiahao

AU - Liu, Guochao

AU - Dong, Chao

AU - Lim, David

AU - Feng, Zhihui

PY - 2020/9

Y1 - 2020/9

N2 - This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

AB - This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inflammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

KW - Breast tumor

KW - DMBA

KW - Macrophage

KW - Sema3c

KW - Valproic acid (VPA)

UR - https://www.scopus.com/pages/publications/85100882642

U2 - 10.1093/TOXRES/TFAA069

DO - 10.1093/TOXRES/TFAA069

M3 - Article

AN - SCOPUS:85100882642

SN - 2045-452X

VL - 9

SP - 609

EP - 621

JO - Toxicology Research

JF - Toxicology Research

IS - 5

ER -

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Abstract

UN SDGs

Keywords

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