The introduction of nanotopography suppresses bacterial adhesion and enhances osteoinductive capacity of plasma deposited polyoxazoline surface

Xujie Liu, Jiongpeng Yuan, Jian Zhang, Rahul Madathiparambil Visalakshan, Wenxia Wang, Yongxiao Xiang, Yan He, Qingling Feng, Krasimir Vasilev

Research output: Contribution to journalArticlepeer-review

Abstract

The plasma deposited polyoxazoline (PPOx) has been emerging in biomedical applications, especially for the surface modification of bone tissue engineering scaffold and/or bone implants. Herein, PPOx surfaces were generated by plasma polymerization with the introduction of surface nanotopography gradient, achieved by immobilization of different density of 16 nm gold nanoparticles. The introduction of surface nanotopography suppressed the adhesion of S. aureus on PPOx surface. Moreover, the introduction of surface nanotopography enhanced the initial attachment and spreading of hMSCs, as well as promoted the osteogenic differentiation of hMSCs. RhoA/ROCK signaling pathway may be involved in the enhancement of osteoinductive capacity of PPOx surface by nanotopography.

Original languageEnglish
Article number131452
Number of pages4
JournalMaterials Letters
Volume309
DOIs
Publication statusPublished - 15 Feb 2022
Externally publishedYes

Keywords

  • Biomaterials
  • Composite materials
  • Osteogenesis
  • Polyoxazoline
  • Surface nanotography

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