The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential

Sylvie Callegari; Ross McKinnon; Stuart Andrews; Miguel de Barros Lopes

doi:10.1016/j.febslet.2011.03.022

The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential

Sylvie Callegari, Ross McKinnon, Stuart Andrews, Miguel de Barros Lopes

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The Saccharomyces cerevisiae MEF2 gene is a mitochondrial protein translation factor. Formerly believed to catalyze peptide elongation, evidence now suggests its involvement in ribosome recycling. This study confirms the role of the MEF2 gene for cell respiration and further uncovers a slow growth phenotype and reduced chronological lifespan. Furthermore, in comparison with cytoplasmic ρ⁰ strains, mef2Δ strains have a marked reduction of the inner mitochondrial membrane potential and mitochondria show a tendency to aggregate, suggesting an additional role for the MEF2 gene in maintenance of mitochondrial health, a role that may also be shared by other mitochondrial protein synthesis factors.

Original language	English
Pages (from-to)	1140-1146
Number of pages	7
Journal	FEBS Letters
Volume	585
Issue number	8
DOIs	https://doi.org/10.1016/j.febslet.2011.03.022
Publication status	Published - 20 Apr 2011

Keywords

Chronological lifespan
MEF2
Mitochondrial membrane potential
Mitochondrial translation
Saccharomyces cerevisiae
Yeast

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10.1016/j.febslet.2011.03.022

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title = "The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential",

abstract = "The Saccharomyces cerevisiae MEF2 gene is a mitochondrial protein translation factor. Formerly believed to catalyze peptide elongation, evidence now suggests its involvement in ribosome recycling. This study confirms the role of the MEF2 gene for cell respiration and further uncovers a slow growth phenotype and reduced chronological lifespan. Furthermore, in comparison with cytoplasmic ρ0 strains, mef2Δ strains have a marked reduction of the inner mitochondrial membrane potential and mitochondria show a tendency to aggregate, suggesting an additional role for the MEF2 gene in maintenance of mitochondrial health, a role that may also be shared by other mitochondrial protein synthesis factors.",

keywords = "Chronological lifespan, MEF2, Mitochondrial membrane potential, Mitochondrial translation, Saccharomyces cerevisiae, Yeast",

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AU - Callegari, Sylvie

AU - McKinnon, Ross

AU - Andrews, Stuart

AU - de Barros Lopes, Miguel

PY - 2011/4/20

Y1 - 2011/4/20

N2 - The Saccharomyces cerevisiae MEF2 gene is a mitochondrial protein translation factor. Formerly believed to catalyze peptide elongation, evidence now suggests its involvement in ribosome recycling. This study confirms the role of the MEF2 gene for cell respiration and further uncovers a slow growth phenotype and reduced chronological lifespan. Furthermore, in comparison with cytoplasmic ρ0 strains, mef2Δ strains have a marked reduction of the inner mitochondrial membrane potential and mitochondria show a tendency to aggregate, suggesting an additional role for the MEF2 gene in maintenance of mitochondrial health, a role that may also be shared by other mitochondrial protein synthesis factors.

AB - The Saccharomyces cerevisiae MEF2 gene is a mitochondrial protein translation factor. Formerly believed to catalyze peptide elongation, evidence now suggests its involvement in ribosome recycling. This study confirms the role of the MEF2 gene for cell respiration and further uncovers a slow growth phenotype and reduced chronological lifespan. Furthermore, in comparison with cytoplasmic ρ0 strains, mef2Δ strains have a marked reduction of the inner mitochondrial membrane potential and mitochondria show a tendency to aggregate, suggesting an additional role for the MEF2 gene in maintenance of mitochondrial health, a role that may also be shared by other mitochondrial protein synthesis factors.

KW - Chronological lifespan

KW - MEF2

KW - Mitochondrial membrane potential

KW - Mitochondrial translation

KW - Saccharomyces cerevisiae

KW - Yeast

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DO - 10.1016/j.febslet.2011.03.022

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JF - FEBS Letters

SN - 0014-5793

IS - 8

ER -

The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential

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Keywords

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