The MEF2 gene is essential for yeast longevity, with a dual role in cell respiration and maintenance of mitochondrial membrane potential

Sylvie Callegari, Ross McKinnon, Stuart Andrews, Miguel de Barros Lopes

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The Saccharomyces cerevisiae MEF2 gene is a mitochondrial protein translation factor. Formerly believed to catalyze peptide elongation, evidence now suggests its involvement in ribosome recycling. This study confirms the role of the MEF2 gene for cell respiration and further uncovers a slow growth phenotype and reduced chronological lifespan. Furthermore, in comparison with cytoplasmic ρ0 strains, mef2Δ strains have a marked reduction of the inner mitochondrial membrane potential and mitochondria show a tendency to aggregate, suggesting an additional role for the MEF2 gene in maintenance of mitochondrial health, a role that may also be shared by other mitochondrial protein synthesis factors.

    Original languageEnglish
    Pages (from-to)1140-1146
    Number of pages7
    JournalFEBS Letters
    Volume585
    Issue number8
    DOIs
    Publication statusPublished - 2011

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