The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

Rosa C. Coldbeck-Shackley, Nicholas S. Eyre, Michael R. Beard

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.

Original languageEnglish
Article number530
Pages (from-to)1-21
Number of pages21
JournalVaccines
Volume8
Issue number3
DOIs
Publication statusPublished - Sep 2020

Bibliographical note

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

  • DENV
  • Evasion
  • IFN
  • Innate immunity
  • Interferon
  • ZIKV

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