The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

Rosa C. Coldbeck-Shackley; Nicholas S. Eyre; Michael R. Beard

doi:10.3390/vaccines8030530

The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

Rosa C. Coldbeck-Shackley, Nicholas S. Eyre, Michael R. Beard

College of Medicine and Public Health

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

47 Downloads (Pure)

Abstract

Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.

Original language	English
Article number	530
Pages (from-to)	1-21
Number of pages	21
Journal	Vaccines
Volume	8
Issue number	3
DOIs	https://doi.org/10.3390/vaccines8030530
Publication status	Published - Sept 2020

Bibliographical note

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

Keywords

DENV
Evasion
IFN
Innate immunity
Interferon
ZIKV

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/vaccines8030530Licence: CC BY

Published versionFinal published version, 3.42 MBLicence: CC BY

Cite this

@article{29c07c76b5ba41548b5ba8a8012d608d,

title = "The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response",

abstract = "Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.",

keywords = "DENV, Evasion, IFN, Innate immunity, Interferon, ZIKV",

author = "Coldbeck-Shackley, {Rosa C.} and Eyre, {Nicholas S.} and Beard, {Michael R.}",

note = "{\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).",

year = "2020",

month = sep,

doi = "10.3390/vaccines8030530",

language = "English",

volume = "8",

pages = "1--21",

journal = "Vaccines",

issn = "2076-393X",

publisher = "MDPI",

number = "3",

}

TY - JOUR

T1 - The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

AU - Coldbeck-Shackley, Rosa C.

AU - Eyre, Nicholas S.

AU - Beard, Michael R.

N1 - © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PY - 2020/9

Y1 - 2020/9

N2 - Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.

AB - Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that cause significant disease in humans. Existing control measures have been ineffective at curbing the increasing global incidence of infection for both viruses and they are therefore prime targets for new vaccination strategies. Type-I interferon (IFN) responses are important in clearing viral infection and for generating efficient adaptive immune responses towards infection and vaccination. However, ZIKV and DENV have evolved multiple molecular mechanisms to evade type-I IFN production. This review covers the molecular interactions, from detection to evasion, of these viruses with the type-I IFN response. Additionally, we discuss how this knowledge can be exploited to improve the design of new vaccine strategies.

KW - DENV

KW - Evasion

KW - IFN

KW - Innate immunity

KW - Interferon

KW - ZIKV

UR - http://www.scopus.com/inward/record.url?scp=85090824943&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/NHMRC/1145613

UR - http://purl.org/au-research/grants/NHMRC/1163662

U2 - 10.3390/vaccines8030530

DO - 10.3390/vaccines8030530

M3 - Article

AN - SCOPUS:85090824943

SN - 2076-393X

VL - 8

SP - 1

EP - 21

JO - Vaccines

JF - Vaccines

IS - 3

M1 - 530

ER -

The Molecular Interactions of ZIKV and DENV with the Type-I IFN Response

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this