The Mutation Profile of Myelodysplastic Syndrome Associated with Auto-Immune Rheumatological Disorders

Lih En Hong, Deepak Singhal, Amilia Wee, Rakchha Chhetri, Mihir D Wechalekar, Susanna Proudman, Devendra K Hiwase

Research output: Contribution to journalMeeting Abstractpeer-review

Abstract

Introduction: A subset of patients with MDS and related myeloid disorders present with concomitant autoimmune rheumatological diseases (AIRD); however the prevalence ranges from 10-48% based on limited literature. Further, use of immunosuppressive agents in AIRD patients could confound the secondary diagnosis of MDS and in some cases cause it (therapy-related myeloid neoplasm; t-MN). The prevalence of cytopenia in AIRD patients is unknown and the genetic characteristics of MDS patients with concomitant AIRD have not been described. Hence, we interrogated two large multi-institutional databases -Royal Adelaide Hospital Rheumatology Database (RAH-RD) and South-Australian MDS (SA-MDS) registry in this study. Methods: Demographic, clinical, laboratory and treatment data of 2663 AIRD and 1157 MDS patients were analysed. In AIRD patients (autoimmune inflammatory arthritis, spondyloarthritis, vasculitis and connective tissue diseases), cytopenia (persisting >6 months) were defined as follows: hemoglobin
Original languageEnglish
Article number3081
Number of pages5
JournalBlood
Volume132
Issue numberSuppl 1
DOIs
Publication statusPublished - 29 Nov 2018
Event60th ASH Annual Meeting & Exposition - San Diego, United States
Duration: 1 Dec 20184 Dec 2018
https://www.hematology.org/meetings/annual-meeting/past-and-upcoming-meetings (List of past ASH annual meetings, including the 60th.)

Keywords

  • Myelodysplastic Syndrome
  • Auto-Immunie
  • Rheumatological Disorders

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