The Mutation Profile of Myelodysplastic Syndrome Associated with Auto-Immune Rheumatological Disorders

Lih En Hong; Deepak Singhal; Amilia Wee; Rakchha Chhetri; Mihir D Wechalekar; Susanna Proudman; Devendra K Hiwase

doi:10.1182/blood-2018-99-119965

The Mutation Profile of Myelodysplastic Syndrome Associated with Auto-Immune Rheumatological Disorders

Lih En Hong, Deepak Singhal, Amilia Wee, Rakchha Chhetri, Mihir D Wechalekar, Susanna Proudman, Devendra K Hiwase

College of Medicine and Public Health

Research output: Contribution to journal › Meeting Abstract › peer-review

Abstract

Introduction: A subset of patients with MDS and related myeloid disorders present with concomitant autoimmune rheumatological diseases (AIRD); however the prevalence ranges from 10-48% based on limited literature. Further, use of immunosuppressive agents in AIRD patients could confound the secondary diagnosis of MDS and in some cases cause it (therapy-related myeloid neoplasm; t-MN). The prevalence of cytopenia in AIRD patients is unknown and the genetic characteristics of MDS patients with concomitant AIRD have not been described. Hence, we interrogated two large multi-institutional databases -Royal Adelaide Hospital Rheumatology Database (RAH-RD) and South-Australian MDS (SA-MDS) registry in this study. Methods: Demographic, clinical, laboratory and treatment data of 2663 AIRD and 1157 MDS patients were analysed. In AIRD patients (autoimmune inflammatory arthritis, spondyloarthritis, vasculitis and connective tissue diseases), cytopenia (persisting >6 months) were defined as follows: hemoglobin

Original language	English
Article number	3081
Number of pages	5
Journal	Blood
Volume	132
Issue number	Suppl 1
DOIs	https://doi.org/10.1182/blood-2018-99-119965
Publication status	Published - 29 Nov 2018
Event	60th ASH Annual Meeting & Exposition - San Diego, United States Duration: 1 Dec 2018 → 4 Dec 2018 https://www.hematology.org/meetings/annual-meeting/past-and-upcoming-meetings (List of past ASH annual meetings, including the 60th.)

Keywords

Myelodysplastic Syndrome
Auto-Immunie
Rheumatological Disorders

Access to Document

10.1182/blood-2018-99-119965Licence: In Copyright

https://www.sciencedirect.com/science/article/pii/S000649711939130X

Cite this

@article{2d79a6c7606d40cb87f5f3b345702912,

title = "The Mutation Profile of Myelodysplastic Syndrome Associated with Auto-Immune Rheumatological Disorders",

abstract = "Introduction: A subset of patients with MDS and related myeloid disorders present with concomitant autoimmune rheumatological diseases (AIRD); however the prevalence ranges from 10-48% based on limited literature. Further, use of immunosuppressive agents in AIRD patients could confound the secondary diagnosis of MDS and in some cases cause it (therapy-related myeloid neoplasm; t-MN). The prevalence of cytopenia in AIRD patients is unknown and the genetic characteristics of MDS patients with concomitant AIRD have not been described. Hence, we interrogated two large multi-institutional databases -Royal Adelaide Hospital Rheumatology Database (RAH-RD) and South-Australian MDS (SA-MDS) registry in this study. Methods: Demographic, clinical, laboratory and treatment data of 2663 AIRD and 1157 MDS patients were analysed. In AIRD patients (autoimmune inflammatory arthritis, spondyloarthritis, vasculitis and connective tissue diseases), cytopenia (persisting >6 months) were defined as follows: hemoglobin ",

keywords = "Myelodysplastic Syndrome, Auto-Immunie, Rheumatological Disorders",

author = "Hong, {Lih En} and Deepak Singhal and Amilia Wee and Rakchha Chhetri and Wechalekar, {Mihir D} and Susanna Proudman and Hiwase, {Devendra K}",

year = "2018",

month = nov,

day = "29",

doi = "10.1182/blood-2018-99-119965",

language = "English",

volume = "132",

journal = "Blood",

issn = "0006-4971",

number = "Suppl 1",

note = "60th ASH Annual Meeting & Exposition ; Conference date: 01-12-2018 Through 04-12-2018",

url = "https://www.hematology.org/meetings/annual-meeting/past-and-upcoming-meetings",

}

TY - JOUR

T1 - The Mutation Profile of Myelodysplastic Syndrome Associated with Auto-Immune Rheumatological Disorders

AU - Hong, Lih En

AU - Singhal, Deepak

AU - Wee, Amilia

AU - Chhetri, Rakchha

AU - Wechalekar, Mihir D

AU - Proudman, Susanna

AU - Hiwase, Devendra K

PY - 2018/11/29

Y1 - 2018/11/29

N2 - Introduction: A subset of patients with MDS and related myeloid disorders present with concomitant autoimmune rheumatological diseases (AIRD); however the prevalence ranges from 10-48% based on limited literature. Further, use of immunosuppressive agents in AIRD patients could confound the secondary diagnosis of MDS and in some cases cause it (therapy-related myeloid neoplasm; t-MN). The prevalence of cytopenia in AIRD patients is unknown and the genetic characteristics of MDS patients with concomitant AIRD have not been described. Hence, we interrogated two large multi-institutional databases -Royal Adelaide Hospital Rheumatology Database (RAH-RD) and South-Australian MDS (SA-MDS) registry in this study. Methods: Demographic, clinical, laboratory and treatment data of 2663 AIRD and 1157 MDS patients were analysed. In AIRD patients (autoimmune inflammatory arthritis, spondyloarthritis, vasculitis and connective tissue diseases), cytopenia (persisting >6 months) were defined as follows: hemoglobin

AB - Introduction: A subset of patients with MDS and related myeloid disorders present with concomitant autoimmune rheumatological diseases (AIRD); however the prevalence ranges from 10-48% based on limited literature. Further, use of immunosuppressive agents in AIRD patients could confound the secondary diagnosis of MDS and in some cases cause it (therapy-related myeloid neoplasm; t-MN). The prevalence of cytopenia in AIRD patients is unknown and the genetic characteristics of MDS patients with concomitant AIRD have not been described. Hence, we interrogated two large multi-institutional databases -Royal Adelaide Hospital Rheumatology Database (RAH-RD) and South-Australian MDS (SA-MDS) registry in this study. Methods: Demographic, clinical, laboratory and treatment data of 2663 AIRD and 1157 MDS patients were analysed. In AIRD patients (autoimmune inflammatory arthritis, spondyloarthritis, vasculitis and connective tissue diseases), cytopenia (persisting >6 months) were defined as follows: hemoglobin

KW - Myelodysplastic Syndrome

KW - Auto-Immunie

KW - Rheumatological Disorders

U2 - 10.1182/blood-2018-99-119965

DO - 10.1182/blood-2018-99-119965

M3 - Meeting Abstract

VL - 132

JO - Blood

JF - Blood

SN - 0006-4971

IS - Suppl 1

M1 - 3081

T2 - 60th ASH Annual Meeting & Exposition

Y2 - 1 December 2018 through 4 December 2018

ER -

The Mutation Profile of Myelodysplastic Syndrome Associated with Auto-Immune Rheumatological Disorders

Abstract

Keywords

Access to Document

Fingerprint

Cite this