The neural correlates of risk propensity in males and females using resting-state fMRI

Yuan Zhou, Shu Li, John Dunn, Huandong Li, Wen Qin, Maohu Zhu, Li-Lin Rao, Ming Song, Chunshui Yu, Tianzi Jiang

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    22 Citations (Scopus)

    Abstract

    Men are more risk prone than women, but the underlying basis remains unclear. To investigate this question, we developed a trait-like measure of risk propensity which we correlated with resting-state functional connectivity to identify sex differences. Specifically, we used short- and long-range functional connectivity densities to identify associated brain regions and examined their functional connectivities in resting-state functional magnetic resonance imaging (fMRI) data collected from a large sample of healthy young volunteers. We found that men had a higher level of general risk propensity (GRP) than women. At the neural level, although they shared a common neural correlate of GRP in a network centered at the right inferior frontal gyrus, men and women differed in a network centered at the right secondary somatosensory cortex, which included the bilateral dorsal anterior/middle insular cortices and the dorsal anterior cingulate cortex. In addition, men and women differed in a local network centered at the left inferior orbitofrontal cortex. Most of the regions identified by this resting-state fMRI study have been previously implicated in risk processing when people make risky decisions. This study provides a new perspective on the brain-behavioral relationships in risky decision making and contributes to our understanding of sex differences in risk propensity.

    Original languageEnglish
    Number of pages13
    JournalFrontiers in Behavioural Neuroscience
    Volume8
    Issue numberJAN
    DOIs
    Publication statusPublished - 28 Jan 2014

    Keywords

    • Functional connectivity
    • Functional magnetic resonance imaging
    • Resting state
    • Risk propensity
    • Sex difference

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  • Cite this

    Zhou, Y., Li, S., Dunn, J., Li, H., Qin, W., Zhu, M., Rao, L-L., Song, M., Yu, C., & Jiang, T. (2014). The neural correlates of risk propensity in males and females using resting-state fMRI. Frontiers in Behavioural Neuroscience, 8(JAN). https://doi.org/10.3389/fnbeh.2014.00002