The novel cytokine Metrnl/IL-41 is elevated in Psoriatic Arthritis synovium and inducible from both entheseal and synovial fibroblasts

Charlie Bridgewood, Tobias Russell, Helen Weedon, Thomas Baboolal, Abdulla Watad, Kassem Sharif, Richard Cuthbert, Miriam Wittmann, Mihir Wechalekar, Dennis McGonagle

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4 Citations (Scopus)

Abstract

Meteorin-like(IL-41), is a novel cytokine that is thought to be immunoregulatory and is highly expressed in psoriatic skin. We investigated IL-41 protein expression in synovial tissue in RA(Rheumatoid Arthritis), PsA(Psoriatic Arthritis) and OA(Osteoarthritis) patients and evaluated IL-41 production from healthy enthesis samples, as the enthesis represent the primary inflammatory site in PsA. IL-41 was measured in synovial fluid from PsA, RA and OA patients. Synovial biopsies were stained for IL-41 by immunohistochemistry. IL-41 was highly expressed in the synovial fluid and synovial tissue of PsA patients (median = 7722 pg/ml) when compared to OA patients (median = 5044 pg/ml). We found that entheseal stromal cells were the dominant producer of IL-41 from the enthesis. Moreover, stromal derived IL-41, could be further induced by IL-17A/F and TNF. In conclusion, IL-41 is expressed in PsA synovium and is present and inducible at the enthesis. Its functional effect in psoriatic inflammation remains to be fully elucidated.

Original languageEnglish
Article number108253
Number of pages5
JournalClinical Immunology
Volume208
DOIs
Publication statusPublished - 1 Nov 2019

Keywords

  • Cytokine
  • Enthesitis
  • Inflammation
  • Psoriatic arthritis
  • Spondyloarthritis
  • Synovium

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    Bridgewood, C., Russell, T., Weedon, H., Baboolal, T., Watad, A., Sharif, K., Cuthbert, R., Wittmann, M., Wechalekar, M., & McGonagle, D. (2019). The novel cytokine Metrnl/IL-41 is elevated in Psoriatic Arthritis synovium and inducible from both entheseal and synovial fibroblasts. Clinical Immunology, 208, [108253]. https://doi.org/10.1016/j.clim.2019.108253