The participation of enteric inhibitory nerves in accommodation of the intestine to distension

J. B. Furness, M. Costa

    Research output: Contribution to journalArticlepeer-review

    24 Citations (Scopus)

    Abstract

    1. The amounts by which various weights distended isolated segments from the distal colons of guinea‐pigs were measured. 2. Tetrodotoxin substantially reduced the distensibility of the intestine, but bretylium, guanethidine, hyoscine and methysergide had no significant effect. 3. It is concluded that a local reflex involving enteric inhibitory nerves causes an accommodation of the intestine to stretch.

    Original languageEnglish
    Pages (from-to)37-41
    Number of pages5
    JournalClinical and Experimental Pharmacology and Physiology
    Volume4
    Issue number1
    DOIs
    Publication statusPublished - Feb 1977

    Keywords

    • autonomic nervous system
    • enteric reflexes
    • intestinal motility
    • peristalsis.

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