The pharmacokinetics of the intravenous steroid anesthetic alphaxalone in the isolated perfused rat lung

Michael E. Jones, Terence E. Nicholas

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    We have examined four mathematical systems modeling the transit of the steroid anesthetic alphaxalone (3α-hydroxy-5α-pregnane-11,20-dione) through the lung. Using the isolated rat lung perfused with a plasma substitute containing14C-alphaxalone and3H-dextran, we have obtained results that are incompatible with models involving (a) anatomical variations in the microcirculation, (b) high solubility, or (c) specific binding. We develop a stochastic model of a physical process analogous to the sequence of events that takes place in a chromatography column. This model closely fits the experimental data and predicts a peak effluent concentration of alphaxalone that may occur after washout with several exclusion volumes. It represents a delay with the pulmonary compartment that may explain a difference in induction times observed between various intravenous anesthetic agents.

    Original languageEnglish
    Pages (from-to)343-355
    Number of pages13
    JournalJournal of Pharmacokinetics and Biopharmaceutics
    Volume9
    Issue number3
    DOIs
    Publication statusPublished - 1 Jun 1981

    Keywords

    • alphaxalone
    • anesthetic
    • lung
    • steroid kinetics

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