TY - JOUR
T1 - The photopic negative response in autism spectrum disorder
AU - Constable, Paul
AU - Lee, Irene
AU - Marmolejo-Ramos, Fernando
AU - Skuse, David
AU - Thompson, Dorothy
PY - 2021/4/7
Y1 - 2021/4/7
N2 - Clinical relevance: To ascertain if the photopic negative response of the electroretinogram is different in autism spectrum disorder as a potential clinical marker. Background: Visual function can be atypical in autism spectrum disorder and structural imaging of the ganglion cell layers has been reported to differ in these individuals. Therefore, we sought to investigate if the photopic negative response of the full field electroretinograms, a measure of ganglion cell function, could help explain the visual perceptual differences in autism spectrum disorder and support the structural changes observed. Methods: Participants (n = 55 autism spectrum disorder, aged 5.4–26.7 years) and control (n = 87, aged 5.4–27.3 years) were recruited for the study. Full-field light-adapted electroretinograms using a Troland protocol with 10 flash strengths from −0.367 to 1.204 log photopic cd.s.m−2 were recorded in each eye. The photopic negative response amplitudes at Tmin and at t = 72 ms were compared between groups along with the a- and b-wave values. Results: There were no significant interactions between groups for the Photopic Negative Response measures of amplitude or time (p > 0.30). There was a group interaction between groups and flash strengths for the b-wave amplitude as previously reported (p < 0.001). Conclusion: The photopic negative response results suggest that there are no significant differences in the summed retinal ganglion cell responses produced by a full-field stimulus.
AB - Clinical relevance: To ascertain if the photopic negative response of the electroretinogram is different in autism spectrum disorder as a potential clinical marker. Background: Visual function can be atypical in autism spectrum disorder and structural imaging of the ganglion cell layers has been reported to differ in these individuals. Therefore, we sought to investigate if the photopic negative response of the full field electroretinograms, a measure of ganglion cell function, could help explain the visual perceptual differences in autism spectrum disorder and support the structural changes observed. Methods: Participants (n = 55 autism spectrum disorder, aged 5.4–26.7 years) and control (n = 87, aged 5.4–27.3 years) were recruited for the study. Full-field light-adapted electroretinograms using a Troland protocol with 10 flash strengths from −0.367 to 1.204 log photopic cd.s.m−2 were recorded in each eye. The photopic negative response amplitudes at Tmin and at t = 72 ms were compared between groups along with the a- and b-wave values. Results: There were no significant interactions between groups for the Photopic Negative Response measures of amplitude or time (p > 0.30). There was a group interaction between groups and flash strengths for the b-wave amplitude as previously reported (p < 0.001). Conclusion: The photopic negative response results suggest that there are no significant differences in the summed retinal ganglion cell responses produced by a full-field stimulus.
KW - Autism spectrum disorder
KW - electroretinogram
KW - ganglion cells
KW - photopic negative response
UR - http://www.scopus.com/inward/record.url?scp=85103890611&partnerID=8YFLogxK
U2 - 10.1080/08164622.2021.1903808
DO - 10.1080/08164622.2021.1903808
M3 - Article
AN - SCOPUS:85103890611
VL - 104
SP - 841
EP - 847
JO - Clinical and Experimental Optometry
JF - Clinical and Experimental Optometry
SN - 0816-4622
IS - 8
ER -