Associação positiva entre ácido úrico sérico, glicemia em jejum alterada, tolerância glicêmica alterada e diabetes mellitus no estudo ELSA-Brasil

Translated title of the contribution: The positive association between serum uric acid, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus in the ELSA-Brasil study

Aline Isabel Rodrigues Galvão, Alline Maria R. Beleigoli, Pedro Guatimosim Vidigal, Bruce Bartholow Duncan, Maria Inês Schmidt, Sarah L. Appleton, Sandhi Maria Barreto, Maria de Fátima Haueisen Sander Diniz

Research output: Contribution to journalArticlepeer-review

Abstract

There is a conflict in the literature regarding the association between serum uric acid (SUA) levels and glycemic status. Therefore, we evaluated the association between SUA level and glycemic status – impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and diabetes mellitus – and insulin resistance, in a large Brazilian study. This is a cross-sectional, observational study with 13,207 participants aged 35-74 years, at baseline (2008-2010) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). A multinomial regression analysis was performed to test the association between SUA and glycemic status (IFG, IGT, and newly diagnosed type 2 diabetes at the cohort baseline) after adjustments by age, sex, skin color, body mass index, physical activity, smoking, alcohol consumption, comorbidities, and medicines use. Logistic regression model was used to evaluate the association between SUA and insulin resistance by HOMA-IR. Stratified analyses by sex were performed. The mean age (standard deviation) was 51.4 (8.9) years, 55.2% of participants were women. There were 1,439 newly diagnosed diabetes. After all adjustments, higher SUA was associated with IFG, IGT, and diabetes, with odds ratio (OR) = 1.15 (95%CI: 1.06; 1.25), 1.23 (95%CI: 1.14; 1.33), and 1.37 (95%CI: 1.24; 1.51), respectively. There was association between SUA levels and insulin resistance with OR = 1.24 (95%CI: 1.13; 1.36). In analysis stratified by sex, higher SUA persisted independently associated with impaired glycemic status. Our results suggest that a higher SUA levels were significantly associated with glycemic status in a large Latin American population, mainly among women.

Translated title of the contributionThe positive association between serum uric acid, impaired fasting glucose, impaired glucose tolerance, and diabetes mellitus in the ELSA-Brasil study
Original languagePortuguese
Article numbere00255920
Pages (from-to)13
JournalCadernos de Saude Publica
Volume37
Issue number9
DOIs
Publication statusPublished - 15 Oct 2021

Keywords

  • Diabetes Mellitus
  • Impaired Glucose Tolerance
  • Insulin Resistance
  • Uric Acid

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