The Potential of Gold Nanoparticle Conjugates to Kill Cancer Cells in Culture

B J S Sanderson; R Lam; J alhahrthi; J Shapter

doi:10.1016/j.proeng.2013.10.004

The Potential of Gold Nanoparticle Conjugates to Kill Cancer Cells in Culture

B J S Sanderson
, R Lam
, J alhahrthi
, J Shapter

Research output: Contribution to conference › Paper › peer-review

6 Citations (Scopus)

66 Downloads (Pure)

Abstract

The anticancer potential of gold nanoparticle conjugates was investigated. The gold nanoparticles were conjugated to paclitaxel (Taxol) to determine if the gold nanoparticle conjugates are as effective at killing cancer cells as the Taxol alone. Cytotoxicity of samples against breast, skin and lung cancer cell lines was determined using the MTT viability assay (a colourimetric assay detecting survival in microplates). The cancer cells were not significantly killed by the gold nanoparticles. However, the skin cancer and breast cancer cells were killed by the Taxol alone and the gold nanoparticle-Taxol conjugate with approximately 65% cell killing at the highest dose.

Original language	English
Pages	26-29
Number of pages	4
DOIs	https://doi.org/10.1016/j.proeng.2013.10.004
Publication status	Published - 2014
Event	ICMAT 2013 - Duration: 30 Jun 2013 → …

Conference

Conference	ICMAT 2013
Period	30/06/13 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
Cell culture
Cytotoxicity
Gold nanoparticles
Paclitaxel
Skin cancer

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10.1016/j.proeng.2013.10.004Licence: CC BY-NC-ND

Sanderson_Potential_P2014Final published version, 316 KBLicence: CC BY-NC-ND

Cite this

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title = "The Potential of Gold Nanoparticle Conjugates to Kill Cancer Cells in Culture",

abstract = "The anticancer potential of gold nanoparticle conjugates was investigated. The gold nanoparticles were conjugated to paclitaxel (Taxol) to determine if the gold nanoparticle conjugates are as effective at killing cancer cells as the Taxol alone. Cytotoxicity of samples against breast, skin and lung cancer cell lines was determined using the MTT viability assay (a colourimetric assay detecting survival in microplates). The cancer cells were not significantly killed by the gold nanoparticles. However, the skin cancer and breast cancer cells were killed by the Taxol alone and the gold nanoparticle-Taxol conjugate with approximately 65\% cell killing at the highest dose.",

keywords = "Breast cancer, Cell culture, Cytotoxicity, Gold nanoparticles, Paclitaxel, Skin cancer",

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year = "2014",

doi = "10.1016/j.proeng.2013.10.004",

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T1 - The Potential of Gold Nanoparticle Conjugates to Kill Cancer Cells in Culture

AU - Sanderson, B J S

AU - Lam, R

AU - alhahrthi, J

AU - Shapter, J

PY - 2014

Y1 - 2014

N2 - The anticancer potential of gold nanoparticle conjugates was investigated. The gold nanoparticles were conjugated to paclitaxel (Taxol) to determine if the gold nanoparticle conjugates are as effective at killing cancer cells as the Taxol alone. Cytotoxicity of samples against breast, skin and lung cancer cell lines was determined using the MTT viability assay (a colourimetric assay detecting survival in microplates). The cancer cells were not significantly killed by the gold nanoparticles. However, the skin cancer and breast cancer cells were killed by the Taxol alone and the gold nanoparticle-Taxol conjugate with approximately 65% cell killing at the highest dose.

AB - The anticancer potential of gold nanoparticle conjugates was investigated. The gold nanoparticles were conjugated to paclitaxel (Taxol) to determine if the gold nanoparticle conjugates are as effective at killing cancer cells as the Taxol alone. Cytotoxicity of samples against breast, skin and lung cancer cell lines was determined using the MTT viability assay (a colourimetric assay detecting survival in microplates). The cancer cells were not significantly killed by the gold nanoparticles. However, the skin cancer and breast cancer cells were killed by the Taxol alone and the gold nanoparticle-Taxol conjugate with approximately 65% cell killing at the highest dose.

KW - Breast cancer

KW - Cell culture

KW - Cytotoxicity

KW - Gold nanoparticles

KW - Paclitaxel

KW - Skin cancer

UR - https://www.scopus.com/pages/publications/84922382058

U2 - 10.1016/j.proeng.2013.10.004

DO - 10.1016/j.proeng.2013.10.004

M3 - Paper

SP - 26

EP - 29

T2 - ICMAT 2013

Y2 - 30 June 2013

ER -

The Potential of Gold Nanoparticle Conjugates to Kill Cancer Cells in Culture

Abstract

Conference

UN SDGs

Keywords

Access to Document

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