The presence of antibodies to human dopamine-β-hydroxylase in commercially available antisera

Robert A. Rush, Sidney Udenfriend

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Three criteria have been used to demonstrate the presence of antibodies to human dopamine-β-hydroxylase in commercially available antisera directed against various human serum fractions. These criteria are the inhibition of enzyme activity, complement fixation and binding of 125I-labelled dopamine-β-hydroxylase to the immobilized antisera. The level of antibody present in some of these antisera was sufficient to allow their use in the radioimmunoassay of the enzyme. The possibility of other useful antibodies occurring in these and similar antisera is suggested.

Original languageEnglish
Pages (from-to)685-691
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume61
Issue number2
DOIs
Publication statusPublished - 27 Nov 1974
Externally publishedYes

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