The projections of 5-hydroxytryptamine-accumulating neurones in the myenteric plexus of the small intestine of the guinea-pig

A. C.B. Meedeniya, S. J.H. Brookes, G. W. Hennig, M. Costa

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Abstract

    Retrograde tracing, combined with immunohistochemistry, was used to study the projections of 5-hydroxytryptamine (5-HT)-accumulating neurones within the ileum of the guinea-pig, with confocal microscopy being used to characterise further their morphology. Two classes of neurones in the myenteric plexus, capable of taking up 5-HT or analogues, were distinguished. One class had Dogiel type I morphology with lamellar dendrites, was located on the edge or in the middle of ganglia and lacked immunoreactivity for somatostatin (SOM). The other class had smooth ovoid cell bodies with multiple filamentous dendrites and a single axon and represented a subset of the SOM-immunoreactive interneurones in the myenteric plexus. Varicosities immunoreactive for 5-HT alone, 5-HT/SOM or SOM alone were present in the myenteric ganglia. Both classes of 5-HT-accumulating neurones had long aboral projections within the myenteric plexus (up to 100 mm long) and to the submucous plexus and probably function as descending interneurones.

    Original languageEnglish
    Pages (from-to)375-384
    Number of pages10
    JournalCell and Tissue Research
    Volume291
    Issue number3
    DOIs
    Publication statusPublished - Feb 1998

    Keywords

    • 5-hydroxytryptamine
    • Chemical coding
    • Guinea-pig
    • Immunohistochemistry
    • Morphology
    • Myenteric neurones
    • Retrograde tracing

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