The regulation of nerve growth factor synthesis and delivery to peripheral neurons

R. A. Rush; R. Mayo; C. Zettler

doi:10.1016/0163-7258(94)00059-C

The regulation of nerve growth factor synthesis and delivery to peripheral neurons

R. A. Rush, R. Mayo, C. Zettler

Research output: Contribution to journal › Review article › peer-review

29 Citations (Scopus)

Abstract

Recent experiments have provided new insights into the way in which the synthesis of nerve growth factor (NGF) is regulated. In particular, a variety of agents have been found to influence the cellular concentration of mRNA^NGF and NGF both in vitro and in vivo. However, no clear mechanism has been found to indicate the existence of a feedback regulation of NGF synthesis by effector tissue innervation. We have argued in this review that some form of feedback control is likely to exist between the innervation and the cells producing the factor. One such possibility, the regulation of the availability of NGF by control of its secretion, is discussed.

Original language	English
Pages (from-to)	93-123
Number of pages	31
Journal	Pharmacology and Therapeutics
Volume	65
Issue number	1
DOIs	https://doi.org/10.1016/0163-7258(94)00059-C
Publication status	Published - 1995

Keywords

disease
feedback regulation
neuronal control
Neurotrophin
physiology
secretion

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AU - Mayo, R.

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AB - Recent experiments have provided new insights into the way in which the synthesis of nerve growth factor (NGF) is regulated. In particular, a variety of agents have been found to influence the cellular concentration of mRNANGF and NGF both in vitro and in vivo. However, no clear mechanism has been found to indicate the existence of a feedback regulation of NGF synthesis by effector tissue innervation. We have argued in this review that some form of feedback control is likely to exist between the innervation and the cells producing the factor. One such possibility, the regulation of the availability of NGF by control of its secretion, is discussed.

KW - disease

KW - feedback regulation

KW - neuronal control

KW - Neurotrophin

KW - physiology

KW - secretion

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ER -

The regulation of nerve growth factor synthesis and delivery to peripheral neurons

Abstract

Keywords

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